Evidence map›Paper›PMID 35017314›Full record

ReviewThorax2022

Lung epithelial cells interact with immune cells and bacteria to shape the microenvironment in tuberculosis.

Amy M de Waal, Pieter S Hiemstra, Tom Hm Ottenhoff, Simone A Joosten, Anne M van der Does

Open access · hybridAbstract readReview
In one paragraph

Review in Thorax, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
  2. Article
  3. HowVaccines · 2026
    Review
  4. Immunodominant Tuberculosis Antigens Recognized by Human CD4Cold Spring Harbor perspectives in medicine · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Silymarin Reduces the Inflammatory Response and the Burden ofInternational journal of microbiology · 2026
    Article
  10. Human lung organoids model for assessing host response toFrontiers in cellular and infection microbiology · 2026
    Article
  11. Article
  12. Article
  13. Innate immune recognition ofCell surface (Amsterdam, Netherlands) · 2025
    Review
  14. Lung epithelial injury impairs early host immune responses to Mycobacterium tuberculosis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Amy M de WaalDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-9121-9216
Pieter S HiemstraDepartment of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-0238-5982
Tom Hm OttenhoffDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.
Simone A Joosten *Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.
Anne M van der Does *Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands a.van_der_does@lumc.nl.
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The lung epithelium has long been overlooked as a key player in tuberculosis disease. In addition to acting as a direct barrier to

Indexed as

Mycobacterium tuberculosisTuberculosisEpithelial CellsHumansImmunity, InnateLungairway epitheliumbacterial infectioninnate immunitylymphocyte biologyrespiratory infectiontuberculosis

Identifiers

PMID35017314
PMCPMC8938665
OpenAlexW4206580303

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.