ArticleProceedings of the National Academy of Sciences of the United States of America2022
Thermodynamic controls on rates of iron oxide reduction by extracellular electron shuttles.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 37 citations in OpenAlex.
- Predicting rates of manganese oxide reduction from thermodynamic driving forces and structural properties.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Integration of Microbial Metabolic Regulation and Abiotic Oxidation: Mechanisms of Artificial Humic Acid-Enhanced Hydroxyl Radical Generation in Paddy Soil.Research (Washington, D.C.) · 2026Article
- Size-Dependent Reduction Kinetics of Iron Oxides in Single and Mixed Mineral Systems.Environmental science & technology · 2025Article
- Reduction Pathway-Dependent Formation of Reactive Fe(II) Sites in Clay Minerals.Environmental science & technology · 2023Article
- Redox Potentials of Magnetite Suspensions under Reducing Conditions.Environmental science & technology · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anaerobic microbial respiration in suboxic and anoxic environments often involves particulate ferric iron (oxyhydr-)oxides as terminal electron acceptors. To ensure efficient respiration, a widespread strategy among iron-reducing microorganisms is the use of extracellular electron shuttles (EES) that transfer two electrons from the microbial cell to the iron oxide surface. Yet, a fundamental understanding of how EES-oxide redox thermodynamics affect rates of iron oxide reduction remains elusive. Attempts to rationalize these rates for different EES, solution pH, and iron oxides on the basis of the underlying reaction free energy of the two-electron transfer were unsuccessful. Here, we demonstrate that broadly varying reduction rates determined in this work for different iron oxides and EES at varying solution chemistry as well as previously published data can be reconciled when these rates are instead related to the free energy of the less exergonic (or even endergonic) first of the two electron transfers from the fully, two-electron reduced EES to ferric iron oxide. We show how free energy relationships aid in identifying controls on microbial iron oxide reduction by EES, thereby advancing a more fundamental understanding of anaerobic respiration using iron oxides.
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