Evidence map›Paper›PMID 35017289›Full record

ArticleNeurosciences (Riyadh, Saudi Arabia)2022

The response patterns of infantile spasms to treatments in 156 patients: Hormonal therapy with intravenous synthetic ACTH appears promising.

Muhammad T Alrifai, Ahmad R Al-Rumayyan, Waleed A Al-Tuwaijri, Duaa M Baarmah, Safiyyah A Asiri, Ahmad H Bali, Muatassem A Alsadhan, Shaden H Alsugheir

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In one paragraph

Article in Neurosciences (Riyadh, Saudi Arabia), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Muhammad T AlrifaiFrom the Department of Pediatrics (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Bali), Neurology Division, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, from the College of Medicine (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Asiri, Bali, Alsadhan, Alsugheir), King Saud bin Abdulaziz University for Health Sciences, and from King Abdullah International Medical Research Center (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Asiri, Bali), Riyadh, Kingdom of Saudi Arabia.
Ahmad R Al-RumayyanFrom the Department of Pediatrics (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Bali), Neurology Division, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, from the College of Medicine (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Asiri, Bali, Alsadhan, Alsugheir), King Saud bin Abdulaziz University for Health Sciences, and from King Abdullah International Medical Research Center (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Asiri, Bali), Riyadh, Kingdom of Saudi Arabia.
Waleed A Al-TuwaijriFrom the Department of Pediatrics (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Bali), Neurology Division, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, from the College of Medicine (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Asiri, Bali, Alsadhan, Alsugheir), King Saud bin Abdulaziz University for Health Sciences, and from King Abdullah International Medical Research Center (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Asiri, Bali), Riyadh, Kingdom of Saudi Arabia.
Duaa M BaarmahFrom the Department of Pediatrics (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Bali), Neurology Division, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, from the College of Medicine (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Asiri, Bali, Alsadhan, Alsugheir), King Saud bin Abdulaziz University for Health Sciences, and from King Abdullah International Medical Research Center (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Asiri, Bali), Riyadh, Kingdom of Saudi Arabia.
Safiyyah A AsiriFrom the Department of Pediatrics (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Bali), Neurology Division, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, from the College of Medicine (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Asiri, Bali, Alsadhan, Alsugheir), King Saud bin Abdulaziz University for Health Sciences, and from King Abdullah International Medical Research Center (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Asiri, Bali), Riyadh, Kingdom of Saudi Arabia.
Ahmad H BaliFrom the Department of Pediatrics (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Bali), Neurology Division, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, from the College of Medicine (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Asiri, Bali, Alsadhan, Alsugheir), King Saud bin Abdulaziz University for Health Sciences, and from King Abdullah International Medical Research Center (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Asiri, Bali), Riyadh, Kingdom of Saudi Arabia.
Muatassem A AlsadhanFrom the Department of Pediatrics (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Bali), Neurology Division, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, from the College of Medicine (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Asiri, Bali, Alsadhan, Alsugheir), King Saud bin Abdulaziz University for Health Sciences, and from King Abdullah International Medical Research Center (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Asiri, Bali), Riyadh, Kingdom of Saudi Arabia.
Shaden H AlsugheirFrom the Department of Pediatrics (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Bali), Neurology Division, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, from the College of Medicine (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Asiri, Bali, Alsadhan, Alsugheir), King Saud bin Abdulaziz University for Health Sciences, and from King Abdullah International Medical Research Center (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Asiri, Bali), Riyadh, Kingdom of Saudi Arabia.
King Saud bin Abdulaziz University for Health Sciences · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo report the efficacy of intravenous (IV) synthetic ACTH (Tetracosactide) in the treatment of infantile spasms.

methodsThis is a retrospective chart review of patients with a diagnosis of infantile spasms conducted at the Pediatric Department of King Abdulaziz Medical City (KAMC) in Riyadh, Saudi Arabia, from 01-01-2005 to 31-12-2019.

resultsOf the 156 cases, 141 were treated initially with vigabatrin (VGB) with a complete response seen in 42(30%). Synthetic ACTH (Tetracosactide) IV injections were used in a total of 52 cases with response in 25(48%). Of the 35 cases which initially failed with VGB, 20(57%) responded to synthetic ACTH. The injections were used as a first line in 8 cases with response in 6(75%). The response to oral steroids was seen in 4/14(29%) cases. A relapse was seen in 2/42(5%) of patients treated with VGB and in 5/25(20%) of those who were treated with synthetic ACTH. The response was highest in the idiopathic group with 7/7(100%). Epilepsy at 2 years was seen in 26/50(52%) and 50/57(88%) of the responders and non-responders, respectively (

Indexed as

AnticonvulsantsCosyntropinSpasms, InfantileAdministration, IntravenousHumansInfantRetrospective StudiesSaudi ArabiaTreatment OutcomeVigabatrinAnticonvulsantsCosyntropinVigabatrin

Identifiers

PMID35017289
PMCPMC9037564
OpenAlexW4206230537

What OpenQuestion holds

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LicenceCC BY-NC
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.