Evidence map›Paper›PMID 35017286›Full record

Observational studyNeurosciences (Riyadh, Saudi Arabia)2022

Clinical delineation of myasthenia gravis in the Kingdom of Bahrain.

Mohamed F Binfalah, Hussein H Alhafnawi, Ahmed A Jaradat, Eslam Shosha, Ali J Alhilly, Firas K Al Nidawi, Mariam M Alhammadi, Moiz O Bakhiet, Fatema M Abdulla

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neurosciences (Riyadh, Saudi Arabia), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohamed F BinfalahFrom Department of Neurology (Binfalah), Department of Family and Community Medicine (Jaradat), Clinical Research Coordinator (Alhafnawi), Aljawhara Center (Bakhiet), Department of Molecular Medicine, Arabian Gulf University, Manama, and from the Neurology and Internal Medicine (Alhilly), Bahrain Defense Force Hospital, West Riffa, from Department of Internal Medicine (Al Nidawi, Alhammadi), King Hamad University Hospital, Busaiteen, from Department of Neurosciences (Abdulla), Salmanya Medical Complex, Ministry of Health, Juffair, Kingdom of Bahrain, and from the Department of Medicine (Shosha), Neurology Division, McMaster University, Hamilton, Canada.
Hussein H AlhafnawiFrom Department of Neurology (Binfalah), Department of Family and Community Medicine (Jaradat), Clinical Research Coordinator (Alhafnawi), Aljawhara Center (Bakhiet), Department of Molecular Medicine, Arabian Gulf University, Manama, and from the Neurology and Internal Medicine (Alhilly), Bahrain Defense Force Hospital, West Riffa, from Department of Internal Medicine (Al Nidawi, Alhammadi), King Hamad University Hospital, Busaiteen, from Department of Neurosciences (Abdulla), Salmanya Medical Complex, Ministry of Health, Juffair, Kingdom of Bahrain, and from the Department of Medicine (Shosha), Neurology Division, McMaster University, Hamilton, Canada.
Ahmed A JaradatFrom Department of Neurology (Binfalah), Department of Family and Community Medicine (Jaradat), Clinical Research Coordinator (Alhafnawi), Aljawhara Center (Bakhiet), Department of Molecular Medicine, Arabian Gulf University, Manama, and from the Neurology and Internal Medicine (Alhilly), Bahrain Defense Force Hospital, West Riffa, from Department of Internal Medicine (Al Nidawi, Alhammadi), King Hamad University Hospital, Busaiteen, from Department of Neurosciences (Abdulla), Salmanya Medical Complex, Ministry of Health, Juffair, Kingdom of Bahrain, and from the Department of Medicine (Shosha), Neurology Division, McMaster University, Hamilton, Canada.
Eslam ShoshaFrom Department of Neurology (Binfalah), Department of Family and Community Medicine (Jaradat), Clinical Research Coordinator (Alhafnawi), Aljawhara Center (Bakhiet), Department of Molecular Medicine, Arabian Gulf University, Manama, and from the Neurology and Internal Medicine (Alhilly), Bahrain Defense Force Hospital, West Riffa, from Department of Internal Medicine (Al Nidawi, Alhammadi), King Hamad University Hospital, Busaiteen, from Department of Neurosciences (Abdulla), Salmanya Medical Complex, Ministry of Health, Juffair, Kingdom of Bahrain, and from the Department of Medicine (Shosha), Neurology Division, McMaster University, Hamilton, Canada.
Ali J AlhillyFrom Department of Neurology (Binfalah), Department of Family and Community Medicine (Jaradat), Clinical Research Coordinator (Alhafnawi), Aljawhara Center (Bakhiet), Department of Molecular Medicine, Arabian Gulf University, Manama, and from the Neurology and Internal Medicine (Alhilly), Bahrain Defense Force Hospital, West Riffa, from Department of Internal Medicine (Al Nidawi, Alhammadi), King Hamad University Hospital, Busaiteen, from Department of Neurosciences (Abdulla), Salmanya Medical Complex, Ministry of Health, Juffair, Kingdom of Bahrain, and from the Department of Medicine (Shosha), Neurology Division, McMaster University, Hamilton, Canada.
Firas K Al NidawiFrom Department of Neurology (Binfalah), Department of Family and Community Medicine (Jaradat), Clinical Research Coordinator (Alhafnawi), Aljawhara Center (Bakhiet), Department of Molecular Medicine, Arabian Gulf University, Manama, and from the Neurology and Internal Medicine (Alhilly), Bahrain Defense Force Hospital, West Riffa, from Department of Internal Medicine (Al Nidawi, Alhammadi), King Hamad University Hospital, Busaiteen, from Department of Neurosciences (Abdulla), Salmanya Medical Complex, Ministry of Health, Juffair, Kingdom of Bahrain, and from the Department of Medicine (Shosha), Neurology Division, McMaster University, Hamilton, Canada.
Mariam M AlhammadiFrom Department of Neurology (Binfalah), Department of Family and Community Medicine (Jaradat), Clinical Research Coordinator (Alhafnawi), Aljawhara Center (Bakhiet), Department of Molecular Medicine, Arabian Gulf University, Manama, and from the Neurology and Internal Medicine (Alhilly), Bahrain Defense Force Hospital, West Riffa, from Department of Internal Medicine (Al Nidawi, Alhammadi), King Hamad University Hospital, Busaiteen, from Department of Neurosciences (Abdulla), Salmanya Medical Complex, Ministry of Health, Juffair, Kingdom of Bahrain, and from the Department of Medicine (Shosha), Neurology Division, McMaster University, Hamilton, Canada.
Moiz O BakhietFrom Department of Neurology (Binfalah), Department of Family and Community Medicine (Jaradat), Clinical Research Coordinator (Alhafnawi), Aljawhara Center (Bakhiet), Department of Molecular Medicine, Arabian Gulf University, Manama, and from the Neurology and Internal Medicine (Alhilly), Bahrain Defense Force Hospital, West Riffa, from Department of Internal Medicine (Al Nidawi, Alhammadi), King Hamad University Hospital, Busaiteen, from Department of Neurosciences (Abdulla), Salmanya Medical Complex, Ministry of Health, Juffair, Kingdom of Bahrain, and from the Department of Medicine (Shosha), Neurology Division, McMaster University, Hamilton, Canada.
Fatema M AbdullaFrom Department of Neurology (Binfalah), Department of Family and Community Medicine (Jaradat), Clinical Research Coordinator (Alhafnawi), Aljawhara Center (Bakhiet), Department of Molecular Medicine, Arabian Gulf University, Manama, and from the Neurology and Internal Medicine (Alhilly), Bahrain Defense Force Hospital, West Riffa, from Department of Internal Medicine (Al Nidawi, Alhammadi), King Hamad University Hospital, Busaiteen, from Department of Neurosciences (Abdulla), Salmanya Medical Complex, Ministry of Health, Juffair, Kingdom of Bahrain, and from the Department of Medicine (Shosha), Neurology Division, McMaster University, Hamilton, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo report demographic and clinical data on 98 myasthenia gravis (MG) patients, seen over 5 years (January 2014-December 2018).

methodsThis was a retrospective, observational cohort study carried out at 3 hospitals in Bahrain. MG was classified into ocular or generalized types. We subdivided MG into early-onset (EOMG, ≤ 49 years) or late-onset (LOMG, > 49 years). Demographic and clinical data were recorded. The data was entered and analyzed using SPSS version 26.0.

results61.2% were females. The mean age at onset was 43.8±17.7 years in males and 43.1±15.7 years in females. 72.4% had EOMG. A pure ocular presentation was most common (51%). Limb weakness was more prevalent in AChR-positive patients. The MuSK group had more severe presentation. 57.1% of patients were AChR-positive, 3.1% MuSK-positive, and 39.8% double-seronegative. Generalized disease onset was more likely with AChR. Abnormal CT chest was seen in 24/69 (35%) including thymic hyperplasia, thymoma, and thymic atrophy. Pathology findings were thymic hyperplasia (55.0%), thymoma (30%), thymolipoma (10%), and normal thymus (5%). Treatment outcomes were favorable.

conclusionThe present study revealed that MG was more common in females, with similar age at onset between males and females. The majority of patients had EOMG with ocular disease and AChR positivity. The clinical outcomes were favorable. Following a standardized protocol for MG diagnosis and workup is recommended.

Indexed as

Myasthenia GravisThymus NeoplasmsAge of OnsetAutoantibodiesBahrainCohort StudiesFemaleHumansMaleAutoantibodies

Identifiers

PMID35017286
PMCPMC9037558

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