Evidence map›Paper›PMID 35017186›Full record

ArticleLupus science & medicine2022

Herpes zoster in SLE: prevalence, incidence and risk factors.

Andrew Kwan, Hanan Al Rayes, Tijana Lazova, Nicole Anderson, Dennisse Bonilla, Jiandong Su, Zahi Touma

Open access · goldAbstract read
In one paragraph

Article in Lupus science & medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Andrew KwanDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada.
Hanan Al RayesDepartment of Medicine, Prince Sultan Military Medical City, Riyadh, Riyadh, Saudi Arabia.
Tijana LazovaSchulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Nicole AndersonCentre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto, Ontario, Canada.
Dennisse BonillaCentre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto, Ontario, Canada.
Jiandong SuCentre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto, Ontario, Canada.
Zahi ToumaDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada Zahi.Touma@uhn.ca.ORCID 0000-0001-5177-2076
University Health Network · CARiyadh Armed Forces Hospital · SAUniversity of Toronto · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to evaluate the prevalence and incidence of herpes zoster (HZ) events and describe its associated factors in a study of patients with SLE.

methods491 consecutive SLE participants were screened for HZ events using a patient-reported questionnaire to capture outcomes on pain and other characteristics associated with HZ events. Sociodemographic, clinical and laboratory measures were also analysed, and time-dependent Cox regression survival analyses were performed to investigate factors associated with HZ events.

resultsPrevalence of HZ was 30.5%, incidence was 14.3 cases per 1000 person-years. Lymphopenia and glucocorticoid dosing were significantly associated with HZ events.

conclusionsHZ is highly prevalent in SLE, which may be linked to disease-related and treatment-related effects on cellular immunity. Our results suggest that the presence of certain risk factors may be useful to allow identification of patients at risk of HZ and improve its management in patients with SLE.

Indexed as

Herpes ZosterLupus Erythematosus, SystemicHumansIncidencePrevalenceRisk Factorsglucocorticoidshealth careoutcome assessmentsystemic lupus erythematosus

Identifiers

PMID35017186
PMCPMC8753438
OpenAlexW4206006306

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.