Evidence map›Paper›PMID 35017127›Full record

ArticleNeuroImage2022

Modulation of brain networks during MR-compatible transcranial direct current stimulation.

Amber M Leaver, Sara Gonzalez, Megha Vasavada, Antoni Kubicki, Mayank Jog, Danny J J Wang, Roger P Woods, Randall Espinoza, Jacqueline Gollan, Todd Parrish and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Perceptual and Cognitive Effects of Focal Transcranial Direct Current Stimulation of Auditory Cortex in Tinnitus.Neuromodulation : journal of the International Neuromodulation Society · 2025
    Trial
  7. Trial
  8. Focal tDCS of auditory cortex in chronic tinnitus: A randomized controlled mechanistic trial.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Trial
  9. Trial
  10. Trial
  11. Article
  12. Auditory Network Discoherence in Chronic Tinnitus.medRxiv : the preprint server for health sciences · 2026
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Amber M LeaverDepartment of Radiology, Northwestern University, Chicago, IL, 60611, United States; Department of Neurology, University of California Los Angeles, Los Angeles, CA, 90095, United States. Electronic address: amber.leaver@northwestern.edu.
Sara GonzalezDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, 90095, United States.
Megha VasavadaDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, 90095, United States.
Antoni KubickiDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, 90095, United States.
Mayank JogDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, 90095, United States.
Danny J J WangLaboratory of FMRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles CA 90033, United States.
Roger P WoodsDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, 90095, United States; Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, 90095, United States.
Randall EspinozaDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, 90095, United States.
Jacqueline GollanDepartment of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, 60611, United States.
Todd ParrishDepartment of Radiology, Northwestern University, Chicago, IL, 60611, United States.
Katherine L NarrDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, 90095, United States; Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, 90095, United States.
University of California, Los Angeles · USNeurobehavioral Systems · USNorthwestern University · USUniversity of Southern California · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Imaging-guided tDCS therapy in major depressionR33MH110526 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NARR, KATHERINE L · 2020 to 2022
$3.2M
Imaging-guided tDCS therapy in major depressionR61MH110526 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NARR, KATHERINE L, WANG, DANNY JJ · 2017 to 2018
$2.2M
Connectome-guided high-definition tDCS for the treatment of tinnitusR21DC015880 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEAVER, AMBER MICHELLE · 2017 to 2019
$470k
NCATS NIH HHS UL1 TR001422NIDCD NIH HHS R21 DC015880NIDCD NIH HHS R61 MH110526NIMH NIH HHS R33 MH110526NIMH NIH HHS R61 MH110526
6 · The paper itself

Abstract

Transcranial direct current stimulation (tDCS) can influence performance on behavioral tasks and improve symptoms of brain conditions. Yet, it remains unclear precisely how tDCS affects brain function and connectivity. Here, we measured changes in functional connectivity (FC) metrics in blood-oxygenation-level-dependent (BOLD) fMRI data acquired during MR-compatible tDCS in a whole-brain analysis with corrections for false discovery rate. Volunteers (n = 64) received active tDCS, sham tDCS, and rest (no stimulation), using one of three previously established electrode tDCS montages targeting left dorsolateral prefrontal cortex (DLPFC, n = 37), lateral temporoparietal area (LTA, n = 16), or superior temporal cortex (STC, n = 11). In brain networks where simulated E field was highest in each montage, connectivity with remote nodes decreased during active tDCS. During active DLPFC-tDCS, connectivity decreased between a fronto-parietal network and subgenual ACC, while during LTA-tDCS connectivity decreased between an auditory-somatomotor network and frontal operculum. Active DLPFC-tDCS was also associated with increased connectivity within an orbitofrontal network overlapping subgenual ACC. Irrespective of montage, FC metrics increased in sensorimotor and attention regions during both active and sham tDCS, which may reflect the cognitive-perceptual demands of tDCS. Taken together, these results indicate that tDCS may have both intended and unintended effects on ongoing brain activity, stressing the importance of including sham, stimulation-absent, and active comparators in basic science and clinical trials of tDCS.

Indexed as

AdultFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeural PathwaysTranscranial Direct Current StimulationfMRIFunctional connectivityTranscranial direct current stimulation

Identifiers

PMID35017127
PMCPMC9623807
OpenAlexW4205369616

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.