ArticleAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2022
Persistent overweight or obesity, lung function, and asthma exacerbations in Puerto Rican youth.
Article in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Overweight, obesity, adiposity measures, and asthma endotypes in Puerto Rican youth.American journal of respiratory and critical care medicine · 2026Article
- Comparison of clinical outcome of COPD with asthma-like feature with different inhalation therapies: a real-world study in the prospective RealDTC cohort.BMC pulmonary medicine · 2025Observational
- Health Disparities in Pediatric Asthma.Respiratory care · 2025Review
- Global burden of asthma attributable to high body mass index in older adults 1990-2021 and prediction to 2050: An analysis of Global Burden of Disease Study 2021.The World Allergy Organization journal · 2025Article
- Relationship between diabetes-related clinical characteristics and preserved ratio impaired spirometry (PRISm): findings from NHANES 2007-2012.BMJ public health · 2024Article
- Association between dietary zinc intake and asthma in overweight or obese children and adolescents: A cross-sectional analysis of NHANES.The World Allergy Organization journal · 2024Article
- Socioeconomic status, diet, and recurrent severe asthma exacerbations in Puerto Rican youth.The journal of allergy and clinical immunology. Global · 2024Article
- Exposure to violence and asthma in Puerto Rican youth with high Th2 immunity.Pediatric pulmonology · 2023Article
- Asthma interactions between obesity and other risk factors.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundWhether persistent overweight or obesity affects lung function or asthma morbidity in youth is unclear.
objectiveTo evaluate overweight or obesity that persists between school age and adolescence and change in lung function and total immunoglobulin (Ig)E and severe asthma exacerbations in Puerto Rican youth.
methodsProspective study of 340 Puerto Rican youth assessed at 2 visits, the first at ages 6 to 14 years and the second at ages 9 to 20 years. Persistent overweight or obesity was defined as a body mass index z-score greater than or equal to 85th percentile at both visits. Outcomes of interest were change in percent predicted (%pred) lung function measures and total IgE between study visits and severe asthma exacerbations in the year before visit 2. Logistic or linear regression was used for multivariable analysis.
resultsIn multivariable analysis, persistently overweight or obese subjects had changes in %pred forced expiratory volume in 1 second (FEV1) (β = -5.07%; 95% confidence interval, -1.51% to -8.62%; P < .01) and %pred FEV1 to forced vital capacity (FVC) ratio (β = -2.85%; 95% confidence interval, -0.18% to -5.51%; P = .04) which were lower than those observed in subjects with normal weight at both study visits (control subjects). Compared with control subjects, those who were persistently overweight or obese and those who became overweight or obese at visit 2 had increased odds of more than or equal to 1 severe asthma exacerbation in the year before visit 2. There was no significant association between persistent overweight or obesity and change in %pred FVC or total IgE (P > .20 for both instances).
conclusionIn a prospective study of Puerto Rican youth, persistently overweight or obese subjects had lower changes in FEV1 or FEV1 to FVC ratio and higher odds of severe asthma exacerbations than subjects of normal weight.
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