Evidence map›Paper›PMID 35016995›Full record

ArticleNeurotoxicology and teratology

Traffic-generated air pollution - Exposure mediated expression of factors associated with demyelination in a female apolipoprotein E

Anna Adivi, JoAnn Lucero, Nicholas Simpson, Jacob D McDonald, Amie K Lund

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Ovarian hormone deficiency enhances wood smoke-induced immune dysfunction via transcriptomic and metabolic alterations.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anna AdiviAdvanced Environmental Research Institute, Department of Biological Sciences, University of North Texas, Denton 76201, TX, USA.
JoAnn LuceroAdvanced Environmental Research Institute, Department of Biological Sciences, University of North Texas, Denton 76201, TX, USA.
Nicholas SimpsonAdvanced Environmental Research Institute, Department of Biological Sciences, University of North Texas, Denton 76201, TX, USA.
Jacob D McDonaldLovelace Biomedical and Environmental Research Institute, Albuquerque 87108, NM, USA.
Amie K LundAdvanced Environmental Research Institute, Department of Biological Sciences, University of North Texas, Denton 76201, TX, USA. Electronic address: amie.lund@unt.edu.

Funding

The Renin-Angiotensin System in Air Pollution-Mediated Exacerbation of Obesity.R15ES026795 · NIEHS · UNIVERSITY OF NORTH TEXAS · PI LUND, AMIE KATHLEEN · 2017 to 2023
$874k
MMP-9 Activity Mediates Vascular Effects of Inhaled Environmental Air PollutantsR00ES016586 · NIEHS · LOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE · PI LUND, AMIE KATHLEEN · 2009 to 2011
$761k
NIEHS NIH HHS R00 ES016586NIEHS NIH HHS R15 ES026795
6 · The paper itself

Abstract

Epidemiology studies suggest that exposure to ambient air pollution is associated with demyelinating diseases in the central nervous system (CNS), including multiple sclerosis (MS). The pathophysiology of MS results from an autoimmune response involving increased inflammation and demyelination in the CNS, which is higher in young (adult) females. Exposure to traffic-generated air pollution is associated with neuroinflammation and other detrimental outcomes in the CNS; however, its role in the progression of pathologies associated with demyelinating diseases has not yet been fully characterized in a female model. Thus, we investigated the effects of inhalation exposure to mixed vehicle emissions (MVE) in the brains of both ovary-intact (ov+) and ovariectomized (ov-) female Apolipoprotein (ApoE

Indexed as

Air PollutionDemyelinating DiseasesAnimalsApolipoproteins EDisease Models, AnimalEstrogen Receptor alphaEstrogen Receptor betaFemaleMiceReactive Oxygen SpeciesVehicle EmissionsApolipoproteins EEstrogen Receptor alphaEstrogen Receptor betaReactive Oxygen SpeciesVehicle EmissionsAir pollutionDemyelinationFemaleInflammationROS

Identifiers

PMID35016995
PMCPMC8904307

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.