ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2022
Higher levels of allograft injury in black patients early after heart transplantation.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Identification of Heart Transplant Rejection Subtypes With Circulating MicroRNAs.Circulation. Heart failure · 2026Article
- From rejection to vasculopathy: a review of non-invasive biomarkers in alloimmune responses in heart transplantation.Frontiers in medicine · 2026Review
- Racial Disparities in Heart Transplantation: Long-Term Graft Survival and Nonmortality Outcomes.Journal of the American Heart Association · 2025Article
- Unique association of extreme elevation of cell free DNA and histologic patterns of intra-alveolar injury among lung transplant recipients.JHLT open · 2025Article
- Heart Transplant Equity: Effect of 2018 Allocation Policy Change on Recipient Mortality and Morbidity by Race and Ethnicity.Journal of the American College of Surgeons · 2025Article
- A modern heart transplant rejection surveillance protocol utilizing cell-free DNA: A single-center experience.JHLT open · 2024Article
- Racial Differences in Donor-Derived Cell-Free DNA and Mitochondrial DNA After Heart Transplantation, on Behalf of the GRAfT Investigators.Circulation. Heart failure · 2024Article
- Advancements in Heart Transplantation: Donor-Derived Cell-Free DNA as Next-Generation Biomarker.Cureus · 2024Review
- Review
- Association of Socioeconomic Position With Racial and Ethnic Disparities in Survival After Lung Transplant.JAMA network open · 2023Article
- Racial disparities in long-term survival after heart transplantation: What should we be telling patients?Clinical transplantation · 2022Article
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Abstract
Black patients suffer higher rates of antibody-mediated rejection and have worse long-term graft survival after heart transplantation. Donor-derived cell free DNA (ddcfDNA) is released into the blood following allograft injury. This study analyzed %ddcfDNA in 63 heart transplant recipients categorized by Black and non-Black race, during the first 200 days after transplant. Immediately after transplant, %ddcfDNA was higher for Black patients (mean [SE]: 8.3% [1.3%] vs 3.2% [1.2%], p = 0.001). In the first week post-transplant, the rate of decay in %ddcfDNA was similar (0.7% [0.68] vs 0.7% [0.11], p = 0.78), and values declined in both groups to a comparable plateau at 7 days post-transplant (0.46% [0.03] vs 0.45% [0.04], p = 0.78). The proportion of Black patients experiencing AMR was higher than non-Black patients (21% vs 9% [hazard ratio of 2.61 [95% confidence interval: 0.651-10.43], p = 0.18). Black patients were more likely to receive a race mismatched organ than non-Black patients (69% vs 35%, p = 0.01), which may explain the higher levels of early allograft injury.
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