ArticleBiology of sex differences2022
Sex differences in sucrose reinforcement in Long-Evans rats.
Article in Biology of sex differences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- On the importance of including both sexes in animal studies - insights from home-cage monitoring.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Disruption of psychostimulant-associated memories by single, low dose ketamine in rats.Neuropharmacology · 2026Article
- Sex differences in hedonic feeding and characterizing the effects of antibiotic-induced microbiome disruption.Research square · 2026Article
- Effects of Cannabidiol on Behavior and Oxidative Stress in a Rat Model of Depression Under Chronic Stress.Journal of xenobiotics · 2026Article
- Predicting alcohol consumption and reward sensitivity using responses for natural sucrose reward in non-food-restricted rats.Psychopharmacology · 2026Article
- dCA1 cells encode and update contextual place preference.Frontiers in systems neuroscience · 2026Article
- Individual differences in stress coping are linked to working memory performance in male and female F344 rats.Physiology & behavior · 2025Article
- Reduction in Reward-Driven Behavior Depends on the Basolateral But Not Central Nucleus of the Amygdala in Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Biomolecular correlates of incubated sucrose-seeking within ventromedial prefrontal cortex are sex- and subregion-selective.Pharmacology, biochemistry, and behavior · 2025Article
- Impact of satiety on palatable food associative learning and consumption in male and female adult rats.Physiology & behavior · 2025Article
- Distinct role of claustrum and anterior cingulate cortex bidirectional circuits in methamphetamine taking and seeking.Nature communications · 2025Article
- Sex differences in motivation to take sucrose following abstinence and environmental enrichment in Long-Evans rats.Physiology & behavior · 2025Article
- Evaluating the impact of concurrent sucrose availability on operant ethanol self-administration in male and female Long Evans rats.Addiction neuroscience · 2025Article
- Sex differences in anxiety and depression: insights from adult rodent models of chronic stress and neural plasticity.Frontiers in behavioral neuroscience · 2025Review
- Short- and long-term changes in neurological, behavioural, and blood biomarkers following repeated mild traumatic brain injury in rats-potential biological sex-dependent effects.Frontiers in molecular neuroscience · 2025Article
- Zoographics in the Journal of the Experimental Analysis of Behavior: Increasing inclusion of female animals.Journal of the experimental analysis of behavior · 2024Article
- Behavioral tests of the insulin-cholinergic-dopamine link in nucleus accumbens and inhibition by high fat-high sugar diet in male and female rats.Physiology & behavior · 2024Article
- Kappa-opioid receptor stimulation in the nucleus accumbens shell and ethanol drinking: Differential effects by rostro-caudal location and level of drinking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Sex- and estrous-related response patterns for alcohol depend critically on the level of compulsion-like challenge.Progress in neuro-psychopharmacology & biological psychiatry · 2024Article
- Validation of the extinction probe trial as a measure of motivation in male and female Long Evans rats.Alcohol, clinical & experimental research · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundThere are sex differences in addiction behaviors. To develop a pre-clinical animal model to investigate this, the present study examined sex differences in sucrose taking and seeking using Long-Evans rats.
methodsFive experiments were conducted using separate groups of subjects. The first two examined sucrose or saccharin preference in two-bottle home cage choice tests. Experiment three assessed sucrose intake in a binge model with sucrose available in home cage bottles. Experiments four and five utilized operant-based procedures. In experiment four rats responded for sucrose on fixed and progressive ratio (FR, PR) schedules of reinforcement over a range of concentrations of sucrose. A final component of experiment four was measuring seeking in the absence of sucrose challenged with the dopamine D1 receptor antagonist SCH23390. Experiment five assessed responding for water on FR and PR schedules of reinforcement.
resultsWhen accounting for body weight, female rats consumed more sucrose than water; but there was no sex difference in saccharin preference over a range of saccharin concentrations. When accounting for body weight, females consumed more sucrose than males in the binge model, and only females increased binge intake over 14 days of the study. Females responded at higher rates for sucrose under both FR and PR schedules of reinforcement. Females responded at higher rates in extinction (seeking); SCH23390 reduced sucrose seeking of both females and males. Females responded at higher rates for water on FR and PR schedules than males, although rates of responding were low and decreased over sessions.
conclusionsAcross bottle-choice, binge intake, and operant procedures, female Long-Evans rats consumed more sucrose and responded at higher rates for sucrose. Although females also responded more for water, the vigor of responding did not explain the consistent sex difference in sucrose taking and seeking. The sex difference in sucrose taking was also not explained by sweet preference, as there was no sex difference in saccharin preference. These data provide a pre-clinical model to further evaluate sex differences in addiction behaviors and manipulations designed to reduce them.
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