ArticleJournal of nanobiotechnology2022
GOx-assisted synthesis of pillar[5]arene based supramolecular polymeric nanoparticles for targeted/synergistic chemo-chemodynamic cancer therapy.
Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Synthesis and host-guest chemistry of a thiophene-extended pillar[6]arene: toward applications in nitroaromatics removal and cell imaging.Frontiers in chemistry · 2026Article
- Recent advances in photodynamic therapy systems based on pillar[n]arene host-guest chemistry.Frontiers in chemistry · 2026Review
- Smart controlled-release delivery ofRSC advances · 2025Article
- Review
- Editorial: Supramolecular cancer therapeutic biomaterials-volume II.Frontiers in chemistry · 2025Article
- Recent Advances in Synthesis and Applications of Calixarene Derivatives Endowed with Anticancer Activity.Molecules (Basel, Switzerland) · 2024Review
- Deep eutectic solvent self-assembled reverse nanomicelles for transdermal delivery of sparingly soluble drugs.Journal of nanobiotechnology · 2024Article
- [Manganese-based nanoparticles for chemodynamic therapy of gastrointestinal cancer].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Pillararene-Based Supramolecular Polymers for Cancer Therapy.Molecules (Basel, Switzerland) · 2023Review
- Supramolecular host-guest nanosystems for overcoming cancer drug resistance.Cancer drug resistance (Alhambra, Calif.) · 2023Review
- A Novel pH-Responsive Iron Oxide Core-Shell Magnetic Mesoporous Silica Nanoparticle (M-MSN) System Encapsulating Doxorubicin (DOX) and Glucose Oxidase (Gox) for Pancreatic Cancer Treatment.International journal of nanomedicine · 2023Article
- Editorial: Supramolecular cancer therapeutic biomaterials.Frontiers in chemistry · 2023Article
- Nano-Theranostics Constructed from Terpyridine-Modified Pillar [5]arene-Based Supramolecular Amphiphile and Its Application in Both Cell Imaging and Cancer Therapy.Molecules (Basel, Switzerland) · 2022Article
- Novel Strategy for Optimized Nanocatalytic Tumor Therapy: From an Updated View.Small science · 2022Article
- Controllable self-assembly of thiophene-based π-conjugated molecule and further construction of pillar[5]arene-based host-guest white-light emission system.Frontiers in chemistry · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundCancer is the most serious world's health problems on the global level and various strategies have been developed for cancer therapy. Pillar[5]arene-based supramolecular therapeutic nano-platform (SP/GOx NPs) was constructed successfully via orthogonal dynamic covalent bonds and intermolecular H-bonds with the assistance of glucose oxidase (GOx) and exhibited efficient targeted/synergistic chemo-chemodynamic cancer therapy.
methodsThe morphology of SP/GOx NPs was characterized by DLS, TEM, SEM and EDS mapping. The cancer therapy efficinecy was investigated both in vivo and in vitro.
resultsSP/GOx NPs can load drug molecules (Dox) and modify target molecule (FA-Py) on its surface conveniently. When the resultant FA-Py/SP/GOx/Dox NPs enters blood circulation, FA-Py will target it to cancer cells efficiently, where GOx can catalyst the overexpressed glucose to generate H
conclusionAll the experiments showed that the excellent antitumor performance of FA-Py/SP/GOx/Dox NPs, which provided an new method for pillar[5]arene-based supramolecular polymer for biomedical applications.
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