SynthesisAdvances in nutrition (Bethesda, Md.)2022
Health Effects of Increasing Protein Intake Above the Current Population Reference Intake in Older Adults: A Systematic Review of the Health Council of the Netherlands.
Synthesis in Advances in nutrition (Bethesda, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Dietary protein and blood pressure: an umbrella review of systematic reviews and evaluation of the evidence.European journal of nutrition · 2024Pooled it
- Protein intake and risk of urolithiasis and kidney diseases: an umbrella review of systematic reviews for the evidence-based guideline of the German Nutrition Society.European journal of nutrition · 2023Pooled it
- Estimating the effect of hypothetical dietary protein interventions on changes in body composition of postmenopausal women over 3 years using data from the Women's Health Initiative (WHI) Study: an emulated target trial.International journal of obesity (2005) · 2026Article
- Association of the Dietary Plant-To-Animal Protein Intake Ratio with the Incidence of Slow Gait Speed in Older Adults.The Journal of nutrition · 2026Article
- Research progress of intestinal microbiota on cognitive dysfunction after spinal cord injury.iScience · 2025Review
- The association between total, animal-based, and plant-based protein intake and cognitive decline in older adults.European journal of nutrition · 2025Article
- Protein Intake and Its Association With Meal Patterns and Dietary Patterns in a Swedish Population of Older Adults.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025Article
- Meal Protein Quality Score: A Novel Tool to Evaluate Protein Quantity and Quality of Meals.Current developments in nutrition · 2024Article
- Does digital technology make people healthier: the impact of digital use on the lifestyle of Chinese older adults.BMC geriatrics · 2024Article
- Discussion on protein recommendations for supporting muscle and bone health in older adults: a mini review.Frontiers in nutrition · 2024Review
- The Association of Isocaloric Substitution of Dietary Protein in Middle Age with Muscle Mass and Strength in Old Age: The Hordaland Health Study.Current developments in nutrition · 2024Article
- The role of nutrition in the prevention of sarcopenia.The American journal of clinical nutrition · 2023Review
- Weight gain during the menopause transition: Evidence for a mechanism dependent on protein leverage.BJOG : an international journal of obstetrics and gynaecology · 2023Article
- Protein - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2023Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whether older adults need more protein than younger adults is debated. The population reference intake for adults set by the European Food Safety Authority is 0.83 g/kg body weight (BW)/d based primarily on nitrogen balance studies, but the underlying data on health outcomes are outdated. An expert committee of the Health Council of the Netherlands conducted a systematic review (SR) of randomized controlled trials (RCTs) examining the effect of increased protein intake on health outcomes in older adults from the general population with an average habitual protein intake ≥0.8 g/(kg BW · d). Exposures were the following: 1) extra protein compared with no protein and 2) extra protein and physical exercise compared with physical exercise. Outcomes included lean body mass, muscle strength, physical performance, bone health, blood pressure, serum glucose and insulin, serum lipids, kidney function, and cognition. Data of >1300 subjects from 18 RCTs were used. Risk of bias was judged as high (n = 9) or "some concerns" (n = 9). In 7 of 18 RCTs, increased protein intake beneficially affected ≥1 of the tested outcome measures of lean body mass. For muscle strength, this applied to 3 of 8 RCTs in the context of physical exercise and in 1 of 7 RCTs without physical exercise. For the other outcomes, <30% (0-29%) of RCTs showed a statistically significant effect. The committee concluded that increased protein intake has a possible beneficial effect on lean body mass and, when combined with physical exercise, muscle strength; likely no effect on muscle strength when not combined with physical exercise, or on physical performance and bone health; an ambiguous effect on serum lipids; and that too few RCTs were available to allow for conclusions on the other outcomes. This SR provides insufficiently convincing data that increasing protein in older adults with a protein intake ≥0.8 g/(kg BW · d) elicits health benefits.
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