Evidence map›Paper›PMID 35016194›Full record

ArticleNature2022

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies.

Yunlong Cao, Jing Wang, Fanchong Jian, Tianhe Xiao, Weiliang Song, Ayijiang Yisimayi, Weijin Huang, Qianqian Li, Peng Wang, Ran An and 20 more

Abstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,320 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,320citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,320 citing papers in PubMed, 1 synthesis or guideline pooled it.

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1,260 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors.

Yunlong Cao *Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, P. R. China. yunlongcao@pku.edu.cn.ORCID http://orcid.org/0000-0001-5918-1078
Jing Wang *Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, P. R. China.ORCID http://orcid.org/0000-0002-9084-9985
Fanchong Jian *Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, P. R. China.ORCID http://orcid.org/0000-0001-8703-3507
Tianhe Xiao *Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, P. R. China.
Weiliang Song *Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, P. R. China.
Ayijiang Yisimayi *Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, P. R. China.
Weijin Huang *Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, P. R. China.ORCID http://orcid.org/0000-0002-4246-8889
Qianqian LiDivision of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, P. R. China.
Peng WangBiomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, P. R. China.
Ran AnBiomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, P. R. China.
Jing WangBiomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, P. R. China.
Yao WangBiomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, P. R. China.
Xiao NiuBiomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, P. R. China.
Sijie YangBiomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, P. R. China.
Hui LiangBiomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, P. R. China.
Haiyan SunBiomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, P. R. China.
Tao LiDivision of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, P. R. China.
Yuanling YuDivision of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, P. R. China.
Qianqian CuiDivision of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, P. R. China.
Shuo LiuDivision of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, P. R. China.
Xiaodong YangBeijing YouAn Hospital, Capital Medical University, Beijing, P. R. China.
Shuo DuSchool of Life Sciences, Peking University, Beijing, P. R. China.ORCID http://orcid.org/0000-0003-0936-0785
Zhiying ZhangSchool of Life Sciences, Peking University, Beijing, P. R. China.ORCID http://orcid.org/0000-0002-5690-9796
Xiaohua HaoBeijing Ditan Hospital, Capital Medical University, Beijing, P. R. China.
Fei ShaoBiomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, P. R. China.
Ronghua JinBeijing Ditan Hospital, Capital Medical University, Beijing, P. R. China.
Xiangxi WangCAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, P. R. China. xiangxi@ibp.ac.cn.
Junyu XiaoBeijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, P. R. China. junyuxiao@pku.edu.cn.ORCID http://orcid.org/0000-0003-1822-1701
Youchun WangDivision of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, P. R. China. wangyc@nifdc.org.cn.ORCID http://orcid.org/0000-0001-9769-5141
Xiaoliang Sunney XieBiomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, P. R. China. sunneyxie@biopic.pku.edu.cn.ORCID http://orcid.org/0000-0001-9281-5239

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SARS-CoV-2 B.1.1.529 (Omicron) variant contains 15 mutations of the receptor-binding domain (RBD). How Omicron evades RBD-targeted neutralizing antibodies requires immediate investigation. Here we use high-throughput yeast display screening

Indexed as

Neutralization TestsAngiotensin-Converting Enzyme 2Antibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralCells, CulturedConvalescenceCOVID-19COVID-19 VaccinesEpitopes, B-LymphocyteHumansImmune EvasionImmune SeraModels, MolecularMutationSARS-CoV-2ACE2 protein, humanAngiotensin-Converting Enzyme 2Antibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesEpitopes, B-LymphocyteImmune SeraSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2

Identifiers

PMID35016194
PMCPMC8866119

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.