ReviewNeuron2022
A functional subdivision within the somatosensory system and its implications for pain research.
Review in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed.
- Distinct parafascicular neuronal ensembles mediate the sensory and affective dimensions of trigeminal neuralgia.The Journal of clinical investigation · 2026Article
- Skeletal interoception regulates joint homeostasis and PGE2-induced pain: implication of disease-modifying treatment.Bone research · 2026Review
- Article
- Article
- Whole-brain mapping of TMS-induced discomfort with large-scale concurrent TMS-fMRI.bioRxiv : the preprint server for biology · 2026Article
- Real-Time and High-Resolution NIR-II-L Imaging of Netrin-1-Mediated Neurovascular Coupling Driven by Dose-Dependent Electroacupuncture.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A randomized trial of a digitally delivered, home-based neuromodulation and mindfulness intervention for pain management in older adults with knee osteoarthritis.NPJ digital medicine · 2026Article
- Ribonuclease 4 Functions in Nociceptor-Mediated Nerve Homeostasis.Nature communications · 2026Article
- Rostral Ventromedial Medulla (RVM) Projects to the Lateral Hypothalamic Area (LHA) to Drive Aversion and Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A molecularly defined basalo-prefrontal-thalamic circuit regulates sensory and affective dimensions of pain in male mice.Nature communications · 2026Article
- Article
- Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses.bioRxiv : the preprint server for biology · 2025Article
- Trigeminal root demyelination is sufficient to induce trigeminal neuralgia-like facial pain in adult rodents.The journal of headache and pain · 2025Article
- Sensory Deficits in Mice with Lateral Spinal Cord Hemisection Mimic the Brown-Séquard Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The dorsal column nuclei encode and transmit the network signatures of mechanical allodynia.Cell reports · 2025Article
- Article
- EEG oscillations reveal neuroplastic changes in pain processing associated with long-term meditation.Scientific reports · 2025Article
- Anatomical characterisation of somatostatin-expressing neurons belonging to the anterolateral system.Scientific reports · 2025Article
- Targeting skeletal interoception: a novel mechanistic insight into intervertebral disc degeneration and pain management.Journal of orthopaedic surgery and research · 2025Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Somatosensory afferents are traditionally classified by soma size, myelination, and their response specificity to external and internal stimuli. Here, we propose the functional subdivision of the nociceptive somatosensory system into two branches. The exteroceptive branch detects external threats and drives reflexive-defensive reactions to prevent or limit injury. The interoceptive branch senses the disruption of body integrity, produces tonic pain with strong aversive emotional components, and drives self-caring responses toward to the injured region to reduce suffering. The central thesis behind this functional subdivision comes from a reflection on the dilemma faced by the pain research field, namely, the use of reflexive-defensive behaviors as surrogate assays for interoceptive tonic pain. The interpretation of these assays is now being challenged by the discovery of distinct but interwoven circuits that drive exteroceptive versus interoceptive types of behaviors, with the conflation of these two components contributing partially to the poor translation of therapies from preclinical studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.