ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2022
The Diagnostic Accuracy of Chest Radiographic Features for Pediatric Intrathoracic Tuberculosis.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Approaches and processes for paediatric chest X-ray classification used in the SHINE TB treatment-shortening trial.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2024Trial
- Predicting radiological severity of pulmonary tuberculosis in children: an assessment of the WHO-criteria and novel prediction scores on an individual participant dataset.medRxiv : the preprint server for health sciences · 2026Article
- Clinical characteristics and risk factors of severe pulmonary tuberculosis in children in Yunnan, China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Computer-aided detection for radiological disease severity classification on chest radiograph in children with intra-thoracic tuberculosis.PLOS global public health · 2026Article
- POCUS Examination of the Mediastinum in Children: A Simplified and Standardized Protocol for Pulmonary Tuberculosis.POCUS journal · 2025Article
- Diagnostic performance of chest radiography for pediatric tuberculosis across high- and low-burden settings.Frontiers in pediatrics · 2025Article
- Deep-learning model accurately classifies multi-label lung ultrasound findings, enhancing diagnostic accuracy and inter-reader agreement.Scientific reports · 2024Article
- Chest X-Ray-Based Telemedicine Platform for Pediatric Tuberculosis Diagnosis in Low-Resource Settings: Development and Validation Study.JMIR pediatrics and parenting · 2024Article
- Evaluation of a short training course of chest X-ray interpretation for the diagnosis of paediatric TB.IJTLD open · 2024Article
- Comparative thoracic radiography in healthy and tuberculosis-positive sun bears (Frontiers in veterinary science · 2024Article
- Artificial Intelligence in Paediatric Tuberculosis.Pediatric radiology · 2023Review
- Optimising computer aided detection to identify intra-thoracic tuberculosis on chest x-ray in South African children.PLOS global public health · 2023Article
- The Contribution of Chest Radiography to the Clinical Management of Children Exposed to Tuberculosis.American journal of respiratory and critical care medicine · 2022Article
- Clinical standards for drug-susceptible pulmonary TB.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022Article
- Morphological manifestation of tuberculous pleurisy in children under medical thoracoscope and diagnostic value.Annals of thoracic medicineArticle
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
introductionThe chest radiograph (CR) remains a key tool in the diagnosis of pediatric tuberculosis (TB). In children with presumptive intrathoracic TB, we aimed to identify CR features that had high specificity for, and were strongly associated with, bacteriologically confirmed TB.
methodsWe analyzed CR data from children with presumptive intrathoracic TB prospectively enrolled in a cohort study in a high-TB burden setting and who were classified using standard clinical case definitions as "confirmed," "unconfirmed," or "unlikely" TB. We report the CR features and inter-reader agreement between expert readers who interpreted the CRs. We calculated the sensitivity and specificity of the CR features with at least moderate inter-reader agreement and analyzed the relationship between these CR features and the classification of TB in a multivariable regression model.
resultsOf features with at least moderate inter-reader agreement, enlargement of perihilar and/or paratracheal lymph nodes, bronchial deviation/compression, cavities, expansile pneumonia, and pleural effusion had a specificity of > 90% for confirmed TB, compared with unlikely TB. Enlargement of perihilar (adjusted odds ratio [aOR]: 6.6; 95% confidence interval [CI], 3.80-11.72) and/or paratracheal lymph nodes (aOR: 5.14; 95% CI, 2.25-12.58), bronchial deviation/compression (aOR: 6.22; 95% CI, 2.70-15.69), pleural effusion (aOR: 2.27; 95% CI, 1.04-4.78), and cavities (aOR: 7.45; 95% CI, 3.38-17.45) were associated with confirmed TB in the multivariate regression model, whereas alveolar opacification (aOR: 1.16; 95% CI, .76-1.77) and expansile pneumonia (aOR: 4.16; 95% CI, .93-22.34) were not.
conclusionsIn children investigated for intrathoracic TB enlargement of perihilar or paratracheal lymph nodes, bronchial compression/deviation, pleural effusion, or cavities on CR strongly support the diagnosis.
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