ArticleAmerican journal of epidemiology2022
Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue.
Article in American journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The neglected association between central obesity markers and abdominal aortic aneurysm presence: A systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Pooled it
- Value of measuring waist circumference in primary care: a mixed-methods study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026Article
- Adiposity-based obesity classification and cardiometabolic and kidney outcomes: a longitudinal UK Biobank analysis.EBioMedicine · 2026Article
- The association of VEGF-A associated gene polymorphisms with obesity and markers of metabolic syndrome in a black South African population.BMC research notes · 2026Article
- Metabolomics of abdominal adipose tissue samples collected from patients with obesity - a critical review.Molecular and cellular biochemistry · 2026Review
- Survey of practices of handling exposure measurement errors in modern epidemiology: are the best practices in statistics being adopted by epidemiologists?BMC medical research methodology · 2025Article
- Prediction Value of Visceral Obesity Related Indices for Visceral Obesity in Chinese Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Article
- Systematic metabolomic studies identified adult adiposity biomarkers with acetylglycine associated with fat lossFrontiers in molecular biosciences · 2023Article
- Dp-ucMGP as a Biomarker in Sarcopenia.Nutrients · 2022Article
- Insights behind the Relationship between Colorectal Cancer and Obesity: Is Visceral Adipose Tissue the Missing Link?International journal of molecular sciences · 2022Review
- Relationship between Metabolic Syndrome Components and COVID-19 Disease Severity in Hospitalized Patients: A Pilot Study.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
Visceral adipose tissue (VAT) is a strong prognostic factor for cardiovascular disease and a potential target for cardiovascular risk stratification. Because VAT is difficult to measure in clinical practice, we estimated prediction models with predictors routinely measured in general practice and VAT as outcome using ridge regression in 2,501 middle-aged participants from the Netherlands Epidemiology of Obesity study, 2008-2012. Adding waist circumference and other anthropometric measurements on top of the routinely measured variables improved the optimism-adjusted R2 from 0.50 to 0.58 with a decrease in the root-mean-square error (RMSE) from 45.6 to 41.5 cm2 and with overall good calibration. Further addition of predominantly lipoprotein-related metabolites from the Nightingale platform did not improve the optimism-corrected R2 and RMSE. The models were externally validated in 370 participants from the Prospective Investigation of Vasculature in Uppsala Seniors (PIVUS, 2006-2009) and 1,901 participants from the Multi-Ethnic Study of Atherosclerosis (MESA, 2000-2007). Performance was comparable to the development setting in PIVUS (R2 = 0.63, RMSE = 42.4 cm2, calibration slope = 0.94) but lower in MESA (R2 = 0.44, RMSE = 60.7 cm2, calibration slope = 0.75). Our findings indicate that the estimation of VAT with routine clinical measurements can be substantially improved by incorporating waist circumference but not by metabolite measurements.
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