ArticleEndocrine connections2022
Non-thyroidal illness syndrome predicts outcome in adult critically ill patients: a systematic review and meta-analysis.
Article in Endocrine connections, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 19 citations in OpenAlex.
- Disrupted thyroid hormone homeostasis in critical illness: clinical correlates and associations with hormone supplementation in a single-center retrospective observational study.Anaesthesiology intensive therapy · 2026Observational
- Non-thyroidal Illness Syndrome and Clinical Outcomes in Critically Ill ICU Patients: A Prospective Cohort Study.Cureus · 2026Article
- Perioperative Thyroid-Metabolic Changes in Pancreatic Ductal Adenocarcinoma According to Surgical Management.Cancers · 2026Article
- Early total triiodothyronine, illness severity, and in-hospital mortality in critically ill adults.Scientific reports · 2026Article
- Prognostic Significance of Dynamic Free T3 Changes in Critically Ill Patients.Clinics and practice · 2026Article
- Early levothyroxine sodium administration and clinical outcomes in patients with sepsis: a MIMIC-IV database analysis.Scientific reports · 2026Article
- The Prognostic Significance of Low-Triiodothyronine Syndrome in Aneurysmal Subarachnoid Hemorrhage.Biomedicines · 2026Article
- Non-thyroidal illness syndrome subtypes and mortality in sepsis: associations with thyroid autoantibodies.Frontiers in endocrinology · 2026Article
- Predictors and Mortality Determinants of Non-Thyroidal Illness Syndrome Among Patients in the Medical Intensive Care Unit in Northeastern Tanzania.Clinical medicine insights. Endocrinology and diabetes · 2026Article
- Non-thyroidal illness (euthyroid sick) syndrome: Laboratory aspects and clinical significance in critically ill patients and other diseases - A narrative review.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026Review
- Thyroid hormone deficiency worsens outcomes in vaccinia virus infection.Journal of virology · 2025Article
- Long-term prognostic value of thyroid hormone levels in chronic critical illness patients.Annals of medicine · 2025Observational
- [Abnormal thyroid markers in critically ill patients-harmless irritation or a real problem?]Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Review
- Critical illness-implications of non-thyroidal illness syndrome and thyroxine therapy.World journal of critical care medicine · 2025Review
- Low urinary selenium concentration is associated with nonthyroidal illness syndrome in hospitalized patients with COVID-19.Archives of endocrinology and metabolism · 2025Article
- Induced Types 2 and 3 Deiodinase in Non-Thyroidal Illness Syndrome and the Implications to Critical Illness-Induced Myopathy-A Prospective Cohort Study.International journal of molecular sciences · 2025Article
- The Impact of Non-Thyroidal Illness Syndromes on The Prognosis and Immune Profile in Severe Fever with Thrombocytopenia Syndrome Patients.Infection and drug resistance · 2025Article
- Impact of thyroid hormone replacement therapy on the course and functional outcome of aneurysmal subarachnoid hemorrhage.Acta neurochirurgica · 2024Article
- Lower Free T3 Levels Linked to Poorer Outcomes in Chronic Obstructive Pulmonary Disease Patients with Acute Hypercapnic Respiratory Failure.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024Article
- Abnormal TSH Level as a Predictor of Severe Outcomes Among Patients Hospitalized With COVID-19.Journal of community hospital internal medicine perspectives · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed a systematic review and meta-analysis to comprehensively determine the prevalence and the prognostic role of non-thyroidal illness syndrome (NTIS) in critically ill patients. We included studies that assessed thyroid function by measuring the serum thyroid hormone (TH) level and in-hospital mortality in adult septic patients. Reviews, case reports, editorials, letters, animal studies, duplicate studies, and studies with irrelevant populations and inappropriate controls were excluded. A total of 6869 patients from 25 studies were included. The median prevalence rate of NTIS was 58% (IQR 33.2-63.7). In univariate analysis, triiodothyronine (T3) and free T3 (FT3) levels in non-survivors were relatively lower than that of survivors (8 studies for T3; standardized mean difference (SMD) 1.16; 95% CI, 0.41-1.92; I2 = 97%; P < 0.01). Free thyroxine (FT4) levels in non-survivors were also lower than that of survivors (12 studies; SMD 0.54; 95% CI, 0.31-0.78; I2 = 83%; P < 0.01). There were no statistically significant differences in thyrotropin levels between non-survivors and survivors. NTIS was independently associated with increased risk of mortality in critically ill patients (odds ratio (OR) = 2.21, 95% CI, 1.64-2.97, I2 = 65% P < 0.01). The results favor the concept that decreased thyroid function might be associated with a worse outcome in critically ill patients. Hence, the measurement of TH could provide prognostic information on mortality in adult patients admitted to ICU.
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