Evidence map›Paper›PMID 35015530›Full record

ArticleJournal of the American Chemical Society2022

Binding Sites of a Positron Emission Tomography Imaging Agent in Alzheimer's β-Amyloid Fibrils Studied Using

Pu Duan, Kelly J Chen, Gayani Wijegunawardena, Aurelio J Dregni, Harrison K Wang, Haifan Wu, Mei Hong

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Binding adaptability of chemical ligands to polymorphic α-synuclein amyloid fibrils.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Article
  13. Molecular Imaging of Systemic and Cardiac Amyloidosis: Recent Advances and Focus on the Future.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Review
  14. Review
  15. Review
  16. Review
  17. EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Review
  19. Article
  20. Solid-State NMRThe journal of physical chemistry. A · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Pu DuanDepartment of Chemistry, Massachusetts Institute of Technology, 170 Albany Street, Cambridge, Massachusetts 02139, United States.ORCID 0000-0002-7395-4353
Kelly J ChenDepartment of Chemistry, Massachusetts Institute of Technology, 170 Albany Street, Cambridge, Massachusetts 02139, United States.
Gayani WijegunawardenaDepartment of Chemistry and Biochemistry, Wichita State University, 1845 Fairmount St., Wichita, Kansas 67260, United States.
Aurelio J DregniDepartment of Chemistry, Massachusetts Institute of Technology, 170 Albany Street, Cambridge, Massachusetts 02139, United States.
Harrison K WangDepartment of Chemistry, Massachusetts Institute of Technology, 170 Albany Street, Cambridge, Massachusetts 02139, United States.
Haifan WuDepartment of Chemistry and Biochemistry, Wichita State University, 1845 Fairmount St., Wichita, Kansas 67260, United States.ORCID 0000-0002-2050-9950
Mei HongDepartment of Chemistry, Massachusetts Institute of Technology, 170 Albany Street, Cambridge, Massachusetts 02139, United States.ORCID 0000-0001-5255-5858
Massachusetts Institute of Technology · USWichita State University · US

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SUSAN J. BROWN · 2012 to 2026
$63.0M
TR&D 4 -- Advanced Magic Angle Spinning NMR methodsP41GM132079 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRIFFIN, ROBERT GUY · 2019 to 2021
$3.6M
Molecular structures of tau aggregates studied by solid-state NMRRF1AG059661 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HONG, MEI · 2018 to 2021
$2.1M
Tau structure and dynamics in Alzheimer's diseaseR01AG059661 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Mei Hong · 2023 to 2026
$1.8M
Investigation of Seeded Alzheimer's Disease Tau Fibrils with Solid-State NMRF31AG069418 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DREGNI, AURELIO JAMES · 2020 to 2021
$85k
NIA NIH HHS F31 AG069418NIA NIH HHS R01 AG059661NIA NIH HHS RF1 AG059661NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P41 GM132079
6 · The paper itself

Abstract

Amyloid imaging by positron emission tomography (PET) is an important method for diagnosing neurodegenerative disorders such as Alzheimer's disease. Many

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesPositron-Emission TomographyAniline CompoundsBenzothiazolesBinding SitesFluorineHumansNuclear Magnetic Resonance, BiomolecularPeptide FragmentsAmyloid beta-PeptidesAniline CompoundsBenzothiazolesFluorineflutemetamolPeptide Fragments

Identifiers

PMID35015530
PMCPMC8855532
OpenAlexW4205799436

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.