Evidence map›Paper›PMID 35015304›Full record

ArticleFEBS letters2022

The T1-tetramerisation domain of Kv1.2 rescues expression and preserves function of a truncated NaChBac sodium channel.

Nazzareno D'Avanzo, Andrew J Miles, Andrew M Powl, Colin G Nichols, B A Wallace, Andrias O O'Reilly

Open access · hybridAbstract read
In one paragraph

Article in FEBS letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nazzareno D'AvanzoDepartment of Pharmacology and Physiology, Université de Montréal, Canada.ORCID 0000-0002-7071-2172
Andrew J MilesInstitute of Structural and Molecular Biology, Birkbeck, University of London, UK.
Andrew M PowlInstitute of Structural and Molecular Biology, Birkbeck, University of London, UK.ORCID 0000-0003-3397-2837
Colin G NicholsDepartment of Cell Biology and Physiology, Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, USA.ORCID 0000-0002-4929-2134
B A WallaceInstitute of Structural and Molecular Biology, Birkbeck, University of London, UK.ORCID 0000-0001-9649-5092
Andrias O O'ReillySchool of Biological & Environmental Sciences, Liverpool John Moores University, UK.ORCID 0000-0003-3449-2368
Institute of Structural and Molecular Biology · GBLiverpool John Moores University · GBUniversité de Montréal · CA

Funding

Role of vascular KATP channels in Alzheimer’s neurodegeneration and dementiaR35HL140024 · NHLBI · WASHINGTON UNIVERSITY · PI NICHOLS, COLIN G · 2018 to 2023
$5.9M
Biotechnology and Biological Sciences Research Council BB/L006790Biotechnology and Biological Sciences Research Council BB/P024092CIHR FRN 173388Medical Research Council MR/W002159/1NHLBI NIH HHS R35 HL140024
6 · The paper itself

Abstract

Cytoplasmic domains frequently promote functional assembly of multimeric ion channels. To investigate structural determinants of this process, we generated the 'T1-chimera' construct of the NaChBac sodium channel by truncating its C-terminal domain and splicing the T1-tetramerisation domain of the Kv1.2 channel to the N terminus. Purified T1-chimera channels were tetrameric, conducted Na

Indexed as

Sodium ChannelsSodium Channelschannel assemblychimeramembrane expressiontetramerisationvoltage-gated channel

Identifiers

PMID35015304
PMCPMC9303580
OpenAlexW4205748672

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.