Trial reportScience China. Life sciences2022
New treatment for amblyopia based on rules of synaptic plasticity: a randomized clinical trial.
Trial report in Science China. Life sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Video Game-Based Interventions for Visual Rehabilitation in Childhood Amblyopia: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2026Review
- Systematic Review and Meta-Analysis of RCTs on Efficacy of Conventional vs. Emerging Treatments for Amblyopia.Life (Basel, Switzerland) · 2026Review
- Regaining Visual Acuity Does Not Restore Motion Extrapolation Deficits in Amblyopia.Investigative ophthalmology & visual science · 2025Article
- Intact Perceptual Interactions of Interocular Temporal Phase and Contrast Disparities in Amblyopia.Investigative ophthalmology & visual science · 2025Article
- Harnessing brain plasticity to improve binocular vision in amblyopia: An evidence-based update.European journal of ophthalmology · 2024Review
- Effects of Monocular Flicker on Binocular Imbalance in Amblyopic and Nonamblyopic Adults.Investigative ophthalmology & visual science · 2024Article
- Measuring the Interocular Delay and its Link to Visual Acuity in Amblyopia.Investigative ophthalmology & visual science · 2024Article
- Improving iconic memory through contrast detection training with HOA-corrected vision.Fundamental research · 2024Article
- Enhancing visual perceptual learning using transcranial electrical stimulation: Transcranial alternating current stimulation outperforms both transcranial direct current and random noise stimulation.Journal of vision · 2023Article
- Perceptual learning based on a temporal stimulus enhances visual function in adult amblyopic subjects.Scientific reports · 2023Article
- Negligible contribution of adaptation of ocular opponency neurons to the effect of short-term monocular deprivation.Frontiers in psychology · 2023Article
- Configuration perceptual learning and its relationship with element perceptual learning.Journal of vision · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amblyopia resulting from early deprivation of vision or defocus in one eye reflects an imbalance of input from the eyes to the visual cortex. We tested the hypothesis that asynchronous stimulation of the two eyes might induce synaptic plasticity and rebalance input. Experiments on normal adults showed that repetitive brief exposure of grating stimuli, with the onset of each stimulus delayed by 8.3 ms in one eye, results in a shift in perceptual eye dominance. Clinical studies (Clinical trial registration number: ChiCTR2100049130), using popular 3D movies with similar asynchrony between the two eyes (amblyopic eye stimulated first) to treat anisometropic amblyopia, established that just 10.5 h of conditioning over <3 weeks produced improvement that met criteria for successful treatment. The benefits of asynchronous conditioning accumulate over 20-30 45 min sessions, and are maintained for at least 2 years. Finally, we demonstrate that asynchronous binocular treatment alone is more effective than patching only. This novel treatment is popular with children and is some 50 times more efficient than patching alone.
Indexed as
Identifiers
35015247What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.