SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022
Early versus the traditional start of oral intake following esophagectomy for esophageal cancer: a systematic review and meta-analysis.
Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.
- The Impact of Early Oral Feeding on Post-Operative Morbidity After Esophagectomy: A Systematic Review and Meta-Analysis.World journal of surgery · 2026Pooled it
- Comparison of timing for early postoperative intake in patients with upper gastrointestinal cancer: a network meta-analysis.BMC surgery · 2026Pooled it
- Preoperative Fibrinogen-to-Prealbumin Ratio and in-Hospital Postoperative Pneumonia After Minimally Invasive McKeown Esophagectomy for Esophageal Squamous Cell Carcinoma: A Retrospective Cohort Study with Infection Phenotype Profiling.Infection and drug resistance · 2026Article
- Early versus late oral feeding regimens following esophagectomy: a propensity score-matched observational cohort.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2025Observational
- Early vs. Late Oral Feeding After Surgery for Patients with Esophageal Malignancy: A Systematic Review and Meta-Analysis of Postoperative Clinical Outcomes and Quality of Life.Journal of personalized medicine · 2025Review
- Machine learning and the nomogram as the accurate tools for predicting postoperative malnutrition risk in esophageal cancer patients.Frontiers in nutrition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNil by mouth is considered the standard of care during the first days following esophagectomy. However, with the routine implementation of enhanced recovery after surgery, early oral intake is more likely to be the preferred mode of nutrition following esophagectomy. The present study aims to evaluate the safety and effectiveness of early oral intake following esophagectomy for esophageal cancer.
methodsComprehensive literature searches were conducted using PubMed, Web of Science, Embase, and Cochrane Library. Weighted mean differences (WMD) and odds ratios (OR) with 95% confidence intervals (CI) were calculated as the effect sizes for continuous and dichotomous variables, respectively.
resultsFourteen studies with a total of 1947 patients were included. Length of hospital stay (WMD = - 3.94, CI: - 4.98 to - 2.90; P < 0.001), the time to first flatus (WMD = - 1.13, CI: - 1.25 to - 1.01; P < 0.001) and defecation (WMD = - 1.26, CI: - 1.82 to - 0.71; P < 0.001) favored the early oral intake group. There was no statistically significant difference in mortality (OR = 1.23, CI: 0.45 to 3.36; P = 0.69). Early oral intake also did not increase the risk of pneumonia and overall postoperative complications.
conclusionsCurrent evidence indicates early oral intake following esophagectomy seems to be safe and effective. It may be the preferred mode of nutrition following esophagectomy. However, more high-quality studies are still needed to further validate this conclusion.
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Registered trials
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