Evidence map›Paper›PMID 35015112›Full record

ArticleEuropean journal of applied physiology2022

Eight weeks of combined exercise training do not alter circulating microRNAs-29a, -133a, -133b, and -155 in young, healthy men.

Cesar A Meza, Manuel Amador, Andrew J McAinch, Khodeza Begum, Sourav Roy, Sudip Bajpeyi

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Article in European journal of applied physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Cesar A MezaMetabolic, Nutrition and Exercise Research (MiNER) Laboratory, Department of Kinesiology, University of Texas at El Paso, 500 W. University Ave, El Paso, TX, 79902, USA.
Manuel AmadorMetabolic, Nutrition and Exercise Research (MiNER) Laboratory, Department of Kinesiology, University of Texas at El Paso, 500 W. University Ave, El Paso, TX, 79902, USA.
Andrew J McAinchInstitute for Health and Sport, Victoria University, Melbourne, VIC, Australia.
Khodeza BegumDepartment of Biological Sciences, Border Biomedical Research Center, University of Texas at El Paso, 500 W. University Ave, El Paso, TX, 79902, USA.
Sourav RoyDepartment of Biological Sciences, Border Biomedical Research Center, University of Texas at El Paso, 500 W. University Ave, El Paso, TX, 79902, USA.
Sudip BajpeyiMetabolic, Nutrition and Exercise Research (MiNER) Laboratory, Department of Kinesiology, University of Texas at El Paso, 500 W. University Ave, El Paso, TX, 79902, USA. sbajpeyi@utep.edu.ORCID http://orcid.org/0000-0002-5336-8330
The University of Texas at El Paso · USAustralian Institute for Musculoskeletal Science · AU

Funding

The University of Texas at El Paso Graduate School Dodson Research Grant
6 · The paper itself

Abstract

purposeIndividuals with a family history of type 2 diabetes (FH +) have an increased risk of developing type 2 diabetes. Circulating microRNAs (miRNAs) have been implicated as biomarkers of type 2 diabetes risk. Here, we investigated if four circulating miRNAs related to glucose metabolism were altered in men with a FH + and we conducted a preliminary analysis to determine if miRNA expressions were responsive to 8 weeks of combined exercise training.

methodsSixteen young healthy men (mean ± SD; age 22.5 ± 2.5; BMI 26.4 ± 4.0) with FH + or without a family history of type 2 diabetes (FH -) underweight 8 weeks of combined endurance and resistance exercise training (n = 8 FH -; n = 8 FH +). The expression of miR-29a, miR-133a, miR-133b, and miR-155 were measured in serum before and after exercise training. QIAGEN's Ingenuity

resultsThere were no differences in miRNA expressions between FH - and FH + . Exercise training did not alter miRNA expressions in either FH - or FH + despite improvements in insulin sensitivity, aerobic capacity, and muscular strength. miR-29a and miR-155 were inversely related to fasting glucose, and miR-133a and miR-133b were negatively correlated with glucose tolerance; however, correlations were not observed with insulin sensitivity.

conclusionsThe circulating miRNAs- miR-29a, miR-133a, miR-133b, and miR-155 are related to measures of glucose metabolism in healthy, normoglycemic men, but do not reflect peripheral insulin sensitivity or improvements in metabolic health following 8 weeks of combined exercise training.

Indexed as

Circulating MicroRNADiabetes Mellitus, Type 2MicroRNAsResistance TrainingAdultExerciseHumansMaleYoung AdultCirculating MicroRNAMicroRNAsCirculating microRNAsCombined exercise trainingFamily history of diabetesInsulin sensitivity

Identifiers

PMID35015112
OpenAlexW4206517765

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.