Evidence map›Paper›PMID 35015056›Full record

ArticleDiabetes care2022

Diabetes Distress in Young Adults With Youth-Onset Type 2 Diabetes: TODAY2 Study Results.

Paula M Trief, Diane Uschner, Melinda Tung, Marsha D Marcus, Maria Rayas, Sarah MacLeish, Ryan Farrell, Joyce Keady, Lily Chao, Ruth S Weinstock

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Guideline
  2. Trial
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  5. Diabetes Distress and its Associated factors among Patients Attending a Tertiary Care Center in Eastern India.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Paula M TriefState University of New York Upstate Medical University, Syracuse, NY.ORCID 0000-0002-2827-5722
Diane UschnerThe Biostatistics Center, George Washington University, Rockville, MD.
Melinda TungThe Biostatistics Center, George Washington University, Rockville, MD.
Marsha D MarcusUniversity of Pittsburgh School of Medicine, Pittsburgh, PA.
Maria RayasUniversity of Texas Health Science Center at San Antonio, San Antonio, TX.
Sarah MacLeishCase Western Reserve University School of Medicine, Cleveland, OH.
Ryan FarrellCase Western Reserve University School of Medicine, Cleveland, OH.
Joyce KeadyJoslin Diabetes Center, Boston, MA.
Lily ChaoChildren's Hospital Los Angeles, Los Angeles, CA.
Ruth S WeinstockState University of New York Upstate Medical University, Syracuse, NY.ORCID 0000-0001-5859-5666
George Washington University · USSUNY Upstate Medical University · USUniversity School · USChildren's Hospital of Los Angeles · USJoslin Diabetes Center · USThe University of Texas Health Science Center at San Antonio · USUniversity of Pittsburgh · US

Funding

Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) StudyU01DK061230 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI BRAFFETT, BARBARA HALINA, ZEITLER, PHILIP S. · 2001 to 2019
$231.8M
Management of Pediatric Type 2 Diabetes MellitusU01DK061239 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI KATZ, LORRAINE E LEVITT · 2001 to 2008
$6.9M
Multi-Center Study of the Treatment of T2DM in YouthU01DK061212 · NIDDK · YALE UNIVERSITY · PI CAPRIO, SONIA · 2001 to 2008
$5.3M
Treatment Alternatives in Pediatric Type 2 DiabetesU01DK061242 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI ZEITLER, PHILIP S. · 2001 to 2008
$5.1M
Type 2 Diabetes in Youth: Beta Cell PreservationU01DK061254 · NIDDK · CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS · PI ARSLANIAN, SILVA A · 2001 to 2007
$4.1M
NIDDK NIH HHS U01 DK061212NIDDK NIH HHS U01 DK061230NIDDK NIH HHS U01 DK061239NIDDK NIH HHS U01 DK061242NIDDK NIH HHS U01 DK061254
6 · The paper itself

Abstract

objectiveTo assess the prevalence of high diabetes distress and associated factors in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY2) study cohort of young adults with youth-onset type 2 diabetes. RESEARCH DESIGN AND

methodsParticipants completed the Diabetes Distress Scale (DDS) at end-of-study visits. Factors examined for association with high distress were demographic (sex, race/ethnicity, age, education, income), medical (HbA1c, BMI, complications), psychological (depressive and anxiety symptoms), and social (number in household, offspring, health care coverage, established with diabetes care provider). Univariate logistic regression identified factors associated with high distress that were controlled for in multivariate logistic regressions.

resultsOf 438 participants, 66% were female (mean age 26.8 years, 18% non-Hispanic White, 37% non-Hispanic Black, 38% Hispanic). High distress (DDS ≥2) was reported by 105 (24%) participants. Subscales identified 40% with high regimen distress and 29.7% with high emotional burden. A greater percentage of those with high distress were female (P = 0.002), diagnosed with hypertension (P = 0.037) and retinopathy (P = 0.005), treated with insulin, had higher HbA1c, and had moderate to severe depressive and anxiety symptoms (all P < 0.001). In multivariate analyses, female sex (P < 0.001), HbA1c (P < 0.001), anxiety symptoms (P = 0.036), and lack of health care coverage (P = 0.019) were associated with high distress, after controlling for potential confounders. Moderate to severe depressive symptoms were associated with high regimen distress (P = 0.018) and emotional burden (P < 0.001); insulin treatment was associated with high emotional burden (P = 0.027).

conclusionsFuture research should identify modifiable factors associated with high diabetes distress in young adults with youth-onset type 2 diabetes that may inform distress interventions with this medically vulnerable group.

Indexed as

Diabetes Mellitus, Type 2AdolescentAdultAnxietyCohort StudiesDepressionEmotionsFemaleHumansInsulinYoung AdultInsulin

Identifiers

PMID35015056
PMCPMC8918198
OpenAlexW4205952403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.