Evidence map›Paper›PMID 35014952›Full record

ArticleeLife2022

Response to comment on 'SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung'.

Alan E Mast, Alisa S Wolberg, David Gailani, Michael R Garvin, Christiane Alvarez, J Izaak Miller, Piet Jones, Bruce Aronow, Daniel Jacobson

Open access · goldAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Alan E Mast *Versiti Blood Research Institute, Department of Cell Biology Neurobiology and Anatomy Medical College of Wisconsin, Milwaukee, United States.ORCID 0000-0003-3740-0318
Alisa S Wolberg *Department of Pathology and Laboratory Medicine and UNC Blood Research Center, Chapel Hill, United States.ORCID 0000-0002-2845-2303
David Gailani *Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, United States.
Michael R GarvinOak Ridge National Laboratory, Biosciences Division, Oak Ridge, United States.ORCID 0000-0002-2204-7569
Christiane AlvarezOak Ridge National Laboratory, Biosciences Division, Oak Ridge, United States.
J Izaak MillerOak Ridge National Laboratory, Biosciences Division, Oak Ridge, United States.
Piet JonesUniversity of Tennessee Knoxville, The Bredesen Center for Interdisciplinary Research and Graduate Education, Knoxville, United States.
Bruce AronowBiomedical Informatics, Cincinnati Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, United States.
Daniel JacobsonOak Ridge National Laboratory, Biosciences Division, Oak Ridge, United States.ORCID 0000-0002-9822-8251
Oak Ridge National Laboratory · USCincinnati Children's Hospital Medical Center · USMedical College of Wisconsin · USUniversity of Tennessee at Knoxville · USVanderbilt University Medical Center · US

Funding

Biochemistry and Pathophysiology of Factor XI and Contact ActivationR35HL140025 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GAILANI, DAVID · 2018 to 2024
$5.5M
Fibrinogen and Factor XIII in Venous ThrombosisR01HL126974 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Alisa S. Wolberg · 2016 to 2026
$4.4M
NHLBI NIH HHS R01 HL126974NHLBI NIH HHS R35 HL140025
6 · The paper itself

Abstract

Early in the SARS-CoV-2 pandemic, we compared transcriptome data from hospitalized COVID-19 patients and control patients without COVID-19. We found changes in procoagulant and fibrinolytic gene expression in the lungs of COVID-19 patients (Mast et al., 2021). These findings have been challenged based on issues with the samples (Fitzgerald and Jamieson, 2022). We have revisited our previous analyses in the light of this challenge and find that these new analyses support our original conclusions.

Indexed as

COVID-19SARS-CoV-2AnticoagulantsHumansLungTranscriptomeAnticoagulantsbronchoalvelolarcoagulationcomputational biologyCOVID-19fibrinolysishumanSARS-CoV-2systems biology

Identifiers

PMID35014952
PMCPMC8752086
OpenAlexW4205799316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.