Evidence map›Paper›PMID 35014934›Full record

ArticleDrug delivery2022

Mitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complex.

Akula S N Murthy, Sanket Das, Tejinder Singh, Tae-Wan Kim, Nasim Sepay, Seob Jeon, Jungkyun Im

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Akula S N MurthyDepartment of Electronic Materials and Devices Engineering, Soonchunhyang University, Asan, South Korea.
Sanket DasDepartment of Chemistry, Pohang University of Science and Technology, Pohang, South Korea.
Tejinder SinghDepartment of Electronic Materials and Devices Engineering, Soonchunhyang University, Asan, South Korea.
Tae-Wan KimDepartment of Medical Life Science, Soonchunhyang University, Asan, South Korea.
Nasim SepayDepartment of Electronic Materials and Devices Engineering, Soonchunhyang University, Asan, South Korea.
Seob JeonDepartment of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, South Korea.
Jungkyun ImDepartment of Electronic Materials and Devices Engineering, Soonchunhyang University, Asan, South Korea.ORCID 0000-0002-7926-5815
Soonchunhyang University · KRPohang University of Science and Technology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As mitochondria are potential therapeutic targeting sites for the treatment of human diseases, delivering cytotoxic drugs, antioxidants, and imaging molecules to mitochondria can provide new therapeutic opportunities. In an attempt to develop a new mitochondria-targeting vector, we synthesized sorbitol-based molecular transporters with multiple guanidines, measured their partition coefficients, compared their targeting efficiency using fluorescent images and Pearson's correlation coefficients, and studied cellular uptake mechanisms. To increase the targeting ability of these molecular transporters to mitochondria, alanine-naphthalene as a lipophilic group was attached to the molecular transporter, which improved translocation across cellular membranes and led to higher accumulation in mitochondria. The molecular transporter was able to form an ionic complex with antibiotics, resulting in low cell viability. These data demonstrate that the molecular transporter with a lipophilic group could be utilized as a potential drug delivery vector for treating mitochondrial dysfunction.

Indexed as

AlanineBiological TransportCell Line, TumorCell MembraneCell SurvivalDrug CarriersGuanidinesHumansMitochondriaNaphthalenesSorbitolAlanineDrug CarriersGuanidinesnaphthaleneNaphthalenesSorbitoldrug deliveryMitochondriamitochondrial dysfunctionmolecular transportertargeted-delivery

Identifiers

PMID35014934
PMCPMC8757599
OpenAlexW4205470012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.