Evidence map›Paper›PMID 35014906›Full record

ArticleRadiology2022

Transarterial Embolization Modulates the Immune Response within Target and Nontarget Hepatocellular Carcinomas in a Rat Model.

David J Tischfield, Alexey Gurevich, Omar Johnson, Isabela Gatmaytan, Gregory J Nadolski, Michael C Soulen, David E Kaplan, Emma Furth, Stephen J Hunt, Terence P F Gade

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
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  16. Observational
  17. Article
  18. Transarterial Chemoembolization for Hepatocellular Carcinoma: Current Role and Techniques.Interventional radiology (Higashimatsuyama-shi (Japan) · 2025
    Review
  19. Article
  20. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

David J Tischfield *From the Penn Image-Guided Interventions Laboratory (D.J.T., A.G., O.J., I.G., G.J.N., S.J.H., T.P.F.G.), Department of Radiology (D.J.T., O.J., G.J.N., M.C.S., S.J.H., T.P.F.G.), and Department of Pathology (E.F.), Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104; Division of Gastroenterology and Hepatology (D.E.K.) and Department of Cancer Biology (T.P.F.G.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; and Gastroenterology Section, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pa (D.E.K.).ORCID 0000-0002-1338-2517
Alexey Gurevich *From the Penn Image-Guided Interventions Laboratory (D.J.T., A.G., O.J., I.G., G.J.N., S.J.H., T.P.F.G.), Department of Radiology (D.J.T., O.J., G.J.N., M.C.S., S.J.H., T.P.F.G.), and Department of Pathology (E.F.), Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104; Division of Gastroenterology and Hepatology (D.E.K.) and Department of Cancer Biology (T.P.F.G.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; and Gastroenterology Section, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pa (D.E.K.).ORCID 0000-0001-8031-2028
Omar JohnsonFrom the Penn Image-Guided Interventions Laboratory (D.J.T., A.G., O.J., I.G., G.J.N., S.J.H., T.P.F.G.), Department of Radiology (D.J.T., O.J., G.J.N., M.C.S., S.J.H., T.P.F.G.), and Department of Pathology (E.F.), Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104; Division of Gastroenterology and Hepatology (D.E.K.) and Department of Cancer Biology (T.P.F.G.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; and Gastroenterology Section, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pa (D.E.K.).ORCID 0000-0001-7644-9064
Isabela GatmaytanFrom the Penn Image-Guided Interventions Laboratory (D.J.T., A.G., O.J., I.G., G.J.N., S.J.H., T.P.F.G.), Department of Radiology (D.J.T., O.J., G.J.N., M.C.S., S.J.H., T.P.F.G.), and Department of Pathology (E.F.), Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104; Division of Gastroenterology and Hepatology (D.E.K.) and Department of Cancer Biology (T.P.F.G.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; and Gastroenterology Section, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pa (D.E.K.).ORCID 0000-0001-8929-5252
Gregory J NadolskiFrom the Penn Image-Guided Interventions Laboratory (D.J.T., A.G., O.J., I.G., G.J.N., S.J.H., T.P.F.G.), Department of Radiology (D.J.T., O.J., G.J.N., M.C.S., S.J.H., T.P.F.G.), and Department of Pathology (E.F.), Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104; Division of Gastroenterology and Hepatology (D.E.K.) and Department of Cancer Biology (T.P.F.G.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; and Gastroenterology Section, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pa (D.E.K.).ORCID 0000-0003-4721-8288
Michael C SoulenFrom the Penn Image-Guided Interventions Laboratory (D.J.T., A.G., O.J., I.G., G.J.N., S.J.H., T.P.F.G.), Department of Radiology (D.J.T., O.J., G.J.N., M.C.S., S.J.H., T.P.F.G.), and Department of Pathology (E.F.), Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104; Division of Gastroenterology and Hepatology (D.E.K.) and Department of Cancer Biology (T.P.F.G.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; and Gastroenterology Section, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pa (D.E.K.).
David E KaplanFrom the Penn Image-Guided Interventions Laboratory (D.J.T., A.G., O.J., I.G., G.J.N., S.J.H., T.P.F.G.), Department of Radiology (D.J.T., O.J., G.J.N., M.C.S., S.J.H., T.P.F.G.), and Department of Pathology (E.F.), Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104; Division of Gastroenterology and Hepatology (D.E.K.) and Department of Cancer Biology (T.P.F.G.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; and Gastroenterology Section, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pa (D.E.K.).ORCID 0000-0002-3839-336X
Emma FurthFrom the Penn Image-Guided Interventions Laboratory (D.J.T., A.G., O.J., I.G., G.J.N., S.J.H., T.P.F.G.), Department of Radiology (D.J.T., O.J., G.J.N., M.C.S., S.J.H., T.P.F.G.), and Department of Pathology (E.F.), Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104; Division of Gastroenterology and Hepatology (D.E.K.) and Department of Cancer Biology (T.P.F.G.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; and Gastroenterology Section, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pa (D.E.K.).ORCID 0000-0002-9309-985X
Stephen J HuntFrom the Penn Image-Guided Interventions Laboratory (D.J.T., A.G., O.J., I.G., G.J.N., S.J.H., T.P.F.G.), Department of Radiology (D.J.T., O.J., G.J.N., M.C.S., S.J.H., T.P.F.G.), and Department of Pathology (E.F.), Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104; Division of Gastroenterology and Hepatology (D.E.K.) and Department of Cancer Biology (T.P.F.G.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; and Gastroenterology Section, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pa (D.E.K.).ORCID 0000-0002-6400-4321
Terence P F GadeFrom the Penn Image-Guided Interventions Laboratory (D.J.T., A.G., O.J., I.G., G.J.N., S.J.H., T.P.F.G.), Department of Radiology (D.J.T., O.J., G.J.N., M.C.S., S.J.H., T.P.F.G.), and Department of Pathology (E.F.), Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104; Division of Gastroenterology and Hepatology (D.E.K.) and Department of Cancer Biology (T.P.F.G.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; and Gastroenterology Section, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pa (D.E.K.).ORCID 0000-0001-8783-0661
Hospital of the University of Pennsylvania · US

Funding

TRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI REBECCA G WELLS · 1997 to 2026
$32.5M
RESEARCH TRACK RADIOLOGY RESIDENCYT32EB004311 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Terence P Gade, Misun Hwang · 2005 to 2026
$4.5M
Targeting Ischemia-Induced Dependencies on the Metabolic Stress Response in Hepatocellular Carcinoma Through Image-Guided, Locoregional TherapyR01CA234005 · NCI · UNIVERSITY OF PENNSYLVANIA · PI GADE, TERENCE P · 2019 to 2023
$2.1M
Image-Based Phenotyping of Hepatocellular Carcinoma Cell Survival Under Ischemic Stress: Toward Metabolic Imaging of Cancer Dormancy Using Hyperpolarized Carbon-13 TechnologyDP5OD021391 · OD · UNIVERSITY OF PENNSYLVANIA · PI GADE, TERENCE P · 2015 to 2019
$2.0M
Cross-comparison of patient-derived xenografts and derivative organoids and cell lines for translational research in hepatocellular carcinomaI01CX001933 · VA · PHILADELPHIA VA MEDICAL CENTER · PI GADE, TERENCE P · 2020 to 2023
–
CSRD VA I01 CX001933NCI NIH HHS R01 CA234005NIBIB NIH HHS T32 EB004311NIDDK NIH HHS P30 DK050306NIH HHS DP5 OD021391
6 · The paper itself

Abstract

Background Transarterial embolization (TAE) is the most common treatment for hepatocellular carcinoma (HCC); however, there remain limited data describing the influence of TAE on the tumor immune microenvironment. Purpose To characterize TAE-induced modulation of the tumor immune microenvironment in a rat model of HCC and identify factors that modulate this response. Materials and Methods TAE was performed on autochthonous HCCs induced in rats with use of diethylnitrosamine. CD3, CD4, CD8, and FOXP3 lymphocytes, as well as programmed cell death protein ligand-1 (

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAnimalsB7-H1 AntigenHumansHydrogelsImmunityRatsTumor MicroenvironmentB7-H1 AntigenHydrogels

Identifiers

PMID35014906
PMCPMC8962821
OpenAlexW4206317851

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.