Evidence map›Paper›PMID 35014736›Full record

ArticleMagnetic resonance in medicine2022

High-resolution quantitative MRI of multiple sclerosis spinal cord lesions.

Amy R McDowell, Natalia Petrova, Daniele Carassiti, Marc E Miquel, David L Thomas, Gareth J Barker, Klaus Schmierer, Tobias C Wood

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amy R McDowellQueen Square Centre for Neuromuscular Diseases, UCL, London, United Kingdom.ORCID 0000-0002-4886-6191
Natalia PetrovaThe Blizard Institute (Neuroscience, Surgery & Trauma), Queen Mary University of London, Barts and The London School of Medicine & Dentistry, London, United Kingdom.
Daniele CarassitiThe Blizard Institute (Neuroscience, Surgery & Trauma), Queen Mary University of London, Barts and The London School of Medicine & Dentistry, London, United Kingdom.ORCID 0000-0002-1664-4324
Marc E MiquelClinical Physics, Barts Health NHS Trust, London, United Kingdom.ORCID 0000-0003-2209-2076
David L ThomasDepartment of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.ORCID 0000-0003-1491-1641
Gareth J BarkerKing's College London, London, United Kingdom.ORCID 0000-0002-5214-7421
Klaus SchmiererThe Blizard Institute (Neuroscience, Surgery & Trauma), Queen Mary University of London, Barts and The London School of Medicine & Dentistry, London, United Kingdom.ORCID 0000-0002-9293-8893
Tobias C WoodKing's College London, London, United Kingdom.ORCID 0000-0001-7640-5520

Funding

Department of HealthWellcome TrustWellcome Trust 539208
6 · The paper itself

Abstract

purposeValidation of quantitative MR measures for myelin imaging in the postmortem multiple sclerosis spinal cord.

methodsFour fixed spinal cord samples were imaged first with a 3T clinical MR scanner to identify areas of interest for scanning, and then with a 7T small bore scanner using a multicomponent-driven equilibrium single-pulse observation of T

resultsExcellent correspondence was found between high-resolution MR parameter maps and histology, particularly for apparent proton density MRI and myelin basic protein staining.

conclusionHigh-resolution quantitative MRI of the spinal cord provides biologically meaningful measures, and could be beneficial to diagnose and track multiple sclerosis lesions in the spinal cord.

Indexed as

Multiple SclerosisHumansMagnetic Resonance ImagingMyelin Basic ProteinMyelin SheathProtonsSpinal CordWaterMyelin Basic ProteinProtonsWatermultiple sclerosismyelin water fractionspinal cord

Identifiers

PMID35014736
PMCPMC9208576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.