ArticleeLife2022
Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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0cells of the map it votes in
20citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Dysregulated serum levels of human tissue kallikreins, hK7 and hK10, as potential biomarkers of asthma.Biochemistry and biophysics reports · 2026Article
- Patient-derived lung organoids from bronchoalveolar lavage capture epithelial heterogeneity and disease biology in bronchopulmonary dysplasia.Redox biology · 2026Article
- Inflammatory drivers of carotid atherosclerosis: signaling pathways, immune cells, and plaque stability.Frontiers in cardiovascular medicine · 2026Review
- Disturbed flow induces reprogramming of endothelial cells to immune-like and foam cells under hypercholesterolaemia during atherogenesis.Cardiovascular research · 2025Article
- Microfluidic Device Type Improves Heart mRNA DeliveryLangmuir : the ACS journal of surfaces and colloids · 2025Article
- Exploring the omnigenic architecture of selected complex traits.American journal of human genetics · 2025Article
- Biophysical and Biochemical Roles of Shear Stress on Endothelium: A Revisit and New Insights.Circulation research · 2025Review
- EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake.Circulation research · 2024Article
- Molecular Mechanisms Regulating Vascular Endothelial Permeability.International journal of molecular sciences · 2024Review
- Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosis.Genes & diseases · 2024Review
- KLK10 derived from tumor endothelial cells accelerates colon cancer cell proliferation and hematogenous liver metastasis formation.Cancer science · 2024Article
- HEG1 Protects Against Atherosclerosis by Regulating Stable Flow-Induced KLF2/4 Expression in Endothelial Cells.Circulation · 2024Article
- LRG1 promotes the apoptosis of pulmonary microvascular endothelial cells through KLK10 in chronic obstructive pulmonary disease.Tobacco induced diseases · 2024Article
- Research Progress of Flavonoids Regulating Endothelial Function.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Diversity of arterial cell and phenotypic heterogeneity induced by high-fat and high-cholesterol diet.Frontiers in cell and developmental biology · 2023Article
- A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion.Journal of the American Chemical Society · 2022Article
- Spatial control of robust transgene expression in mouse artery endothelium under ultrasound guidance.Signal transduction and targeted therapy · 2022Article
- New Insights into Cerebral Vessel Disease Landscapes at Single-Cell Resolution: Pathogenetic and Therapeutic Perspectives.Biomedicines · 2022Review
- Single-cell RNA sequencing in atherosclerosis: Mechanism and precision medicine.Frontiers in pharmacology · 2022Review
- Sox13 is a novel flow-sensitive transcription factor that prevents inflammation by repressing chemokine expression in endothelial cells.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
22 authors at 9 institutions in 6 countries.
Darian Williams *Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, United States.ORCID 0000-0002-4572-3056
Marwa Mahmoud *Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, United States.
Renfa Liu *Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, United States.
Aitor AnduezaCoulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, United States.
Sandeep KumarCoulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, United States.
Dong-Won KangCoulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, United States.
Jiahui ZhangCoulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, United States.
Ian TamargoMolecular and Systems Pharmacology Program, Emory University, Atlanta, United States.
Nicolas Villa-RoelCoulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, United States.ORCID 0000-0002-2981-9330
Kyung-In BaekCoulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, United States.
Hwakyoung LeeCelltrion, Incheon, Republic of Korea.
Yongjin AnCelltrion, Incheon, Republic of Korea.
Leran ZhangDepartment of Chemistry, Imperial College London, London, United Kingdom.
Edward W TateDepartment of Chemistry, Imperial College London, London, United Kingdom.
Pritha BagchiEmory Integrated Proteomics Core, Emory University, Atlanta, United States.
Jan PohlBiotechnology Core Facility Branch, Centers for Disease Control and Prevention, Atlanta, United States.
Laurent O MosnierDepartment of Molecular Medicine, Scripps Research Institute, San Diego, United States.
Eleftherios P DiamandisDepartment of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada.ORCID 0000-0002-1589-820X
Koichiro MiharaDepartment of Physiology and Pharmacology, University of Calgary, Calgary, Canada.
Morley D HollenbergDepartment of Physiology and Pharmacology, University of Calgary, Calgary, Canada.
Zhifei DaiDepartment of Biomedical Engineering, Peking University, Beijing, China.
Hanjoong JoCoulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, United States.ORCID 0000-0003-1833-372X
Georgia Institute of Technology · USCelltrion (South Korea) · KREmory University · USImperial College London · GBUniversity of Calgary · CACenters for Disease Control and Prevention · USMount Sinai Hospital · CAPeking University · CNScripps Research Institute · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3MRegulation of Protein C PathwaysR01HL142975 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI GRIFFIN, JOHN H, MOSNIER, LAURENT OLIVIER · 2018 to 2025
$7.3MStructure-function of cytoprotective coagulation proteases and their receptorsR01HL104165 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI MOSNIER, LAURENT OLIVIER · 2011 to 2024
$6.1MGraduate Training in the Pharmacological StudiesT32GM008602 · NIGMS · EMORY UNIVERSITY · PI HALL, RANDY A. · 1996 to 2021
$5.1MShear stress, endothelial miRNAs, and AV calcificationR01HL119798 · NHLBI · EMORY UNIVERSITY · PI JO, HANJOONG · 2013 to 2022
$4.7MHEG1 in endothelial function and atherosclerosisR01HL158571 · NHLBI · EMORY UNIVERSITY · PI JO, HANJOONG · 2021 to 2024
$2.7MNovel functions of Thrombin Activatable Fibrinolysis Inhibitor (TAFI)R01HL148096 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI MOSNIER, LAURENT OLIVIER · 2020 to 2023
$2.6MRole of flow-sensitive KLK10 in endothelial dysfunction and atherosclerosisR01HL139757 · NHLBI · EMORY UNIVERSITY · PI JO, HANJOONG · 2018 to 2021
$1.6MRole of KLK10 in Endothelial Biology and AtherosclerosisF31HL145974 · NHLBI · EMORY UNIVERSITY · PI WILLIAMS, DARIAN · 2019 to 2021
$134kCancer Research UK C24523/A25192NHLBI NIH HHS F31 HL145974NHLBI NIH HHS R01 HL104165NHLBI NIH HHS R01 HL119798NHLBI NIH HHS R01 HL139757NHLBI NIH HHS R01 HL142975NHLBI NIH HHS R01 HL148096NHLBI NIH HHS R01 HL158571NIGMS NIH HHS T32 GM008169NIGMS NIH HHS T32 GM008602
Abstract
Atherosclerosis preferentially occurs in arterial regions exposed to disturbed blood flow (
Indexed as
Gene Expression RegulationAnimalsAtherosclerosisEndothelial CellsInflammationKallikreinsMaleMiceMice, Inbred C57BLKallikreinsKlk10 protein, mouseatherosclerosiscell biologyendothelial cellshumanimmunologyinflammationkallikreinsmechanobiologymouseshear stress
Identifiers
What OpenQuestion holds
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LicenceCC0
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.