Evidence map›Paper›PMID 35014480›Full record

ArticleACS applied bio materials2021

Photograftable Zwitterionic Coatings Prevent

Na Shen, Elise Cheng, John W Whitley, Ryan R Horne, Braden Leigh, Linjing Xu, Bradley D Jones, C Allan Guymon, Marlan R Hansen

Abstract read
In one paragraph

Article in ACS applied bio materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
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  4. Review
  5. Article
  6. Pentadecanoic Acid-Releasing PDMS: Towards a New Material to PreventInternational journal of molecular sciences · 2024
    Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Na ShenDepartment of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa 52242, United States.
Elise ChengDepartment of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa 52242, United States.
John W WhitleyDepartment of Chemical and Biochemical Engineering, University of Iowa, Iowa City, Iowa 52242, United States.
Ryan R HorneDepartment of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa 52242, United States.
Braden LeighDepartment of Chemical and Biochemical Engineering, University of Iowa, Iowa City, Iowa 52242, United States.
Linjing XuDepartment of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa 52242, United States.
Bradley D JonesDepartment of Microbiology and Immunology, University of Iowa, Iowa City, Iowa 52242, United States.
C Allan GuymonDepartment of Chemical and Biochemical Engineering, University of Iowa, Iowa City, Iowa 52242, United States.ORCID 0000-0002-3351-9621
Marlan R HansenDepartment of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa 52242, United States.ORCID 0000-0002-6884-4897

Funding

The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
The University of Iowa Clinical and Translational Science AwardU54TR001356 · NCATS · UNIVERSITY OF IOWA · PI WINOKUR, PATRICIA · 2015 to 2016
$7.1M
Reduction of Intracochlear Trauma and Fibrosis Using Dual Network, Zwitterionic Hydrogel Thin Films on Cochlear Implant SurfacesR01DC012578 · NIDCD · UNIVERSITY OF IOWA · PI Allan Guymon, Marlan R Hansen · 2013 to 2026
$6.3M
Research Training Program in OtolaryngologyT32DC000040 · NIDCD · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R · 1993 to 2025
$5.4M
NCATS NIH HHS U54 TR001356NCATS NIH HHS UL1 TR002537NIDCD NIH HHS R01 DC012578NIDCD NIH HHS T32 DC000040
6 · The paper itself

Abstract

Due to its attractive mechanical properties and biocompatibility, poly(dimethyl)siloxane (PDMS) is widely used in the fabrication of biomedical materials. On the other hand, PDMS is also prone to adsorption of both proteins and bacteria, making PDMS implants susceptible to infection. Herein, we examine the use of durably cross-linked zwitterionic coatings for PDMS surfaces to mitigate bacterial adhesion. Using a single-step photografting technique, poly(sulfobetaine methacrylate) (pSBMA) and poly(carboxybetaine methacrylate) (pCBMA) thin films were covalently attached to PDMS substrates. The abilities of these coatings to resist the adhesion of

Indexed as

Bacterial AdhesionPhotochemical ProcessesAnimalsBiocompatible MaterialsBiofilmsBiofoulingDimethylpolysiloxanesImplants, ExperimentalRatsRats, Sprague-DawleyStaphylococcus aureusStaphylococcus epidermidisSurface PropertiesBiocompatible MaterialsDimethylpolysiloxanesanti-adhesionantibacterial coatingsanti-foulingin vivo implant protectionsurface modificationszwitterionic hydrogels

Identifiers

PMID35014480
PMCPMC9287762

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.