Evidence map›Paper›PMID 35014222›Full record

ArticleAnnals of clinical and translational neurology2022

Reliability of patient self-report of cognition, awareness, and consciousness during seizures.

Charlie W Zhao, Rahiwa Gebre, Yigit Baykara, William Chen, Petr Vitkovskiy, Ningcheng Li, Michelle Johnson, Eric Y Chen, Dan Kluger, Hal Blumenfeld

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Evaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testingEpileptic disorders : international epilepsy journal with videotape · 2022
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Charlie W ZhaoDepartments of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, USA.
Rahiwa GebreDepartments of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, USA.
Yigit BaykaraDepartments of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, USA.
William ChenDepartments of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, USA.
Petr VitkovskiyDepartments of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, USA.
Ningcheng LiDepartments of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, USA.
Michelle JohnsonDepartments of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, USA.
Eric Y ChenDepartments of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, USA.
Dan KlugerDepartments of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, USA.
Hal BlumenfeldDepartments of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, USA.ORCID 0000-0003-0812-8132

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Betsy and Jonathan Blattmachr familyJames G. Hirsch, MD medical student research fellowshipMark Loughridge and Michele Williams FoundationNCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

objectiveClinicians rely on patient self-report of impairment during seizures for decisions including driving eligibility. However, the reliability of patient reports on cognitive and behavioral functions during seizures remains unknown.

methodsWe administered a daily questionnaire to epilepsy patients undergoing continuous video-EEG monitoring, asking about responsiveness, speech, memory, awareness, and consciousness during seizures in the preceding 24 hours. We also administered a questionnaire upon admission about responsiveness, speech, and awareness during seizures. Subjective questionnaire answers were compared with objective behavioral ratings on video review. Criteria for agreement were Cohen's kappa >0.60 and proportions of positive and negative agreement both >0.75.

resultsWe analyzed 86 epileptic seizures in 39 patients. Memory report on the daily questionnaire met criteria for agreement with video review (κ = 0.674 for early, 0.743 for late recall). Subjective report of awareness also met agreement criteria with video ratings of memory (κ = 0.673 early, 0.774 late). Concordance for speech was relatively good (κ = 0.679) but did not meet agreement criteria, nor did responsiveness or consciousness. On the admission questionnaire, agreement criteria were met for subjective report of awareness versus video ratings of memory (κ = 0.814 early, 0.806 late), but not for other comparisons.

interpretationPatient self-report of memory or awareness showed the best concordance with objective memory impairment during seizures. Self-report of impairment in other categories was less reliable. These findings suggest that patient reports about impaired memory during seizures may be most reliable, and otherwise determining functional impairments should be based on objective observations.

Indexed as

Diagnostic Self EvaluationAdultAwarenessCognitionConsciousnessEpilepsyFemaleHumansMaleMiddle AgedReproducibility of ResultsSelf Report

Identifiers

PMID35014222
PMCPMC8791805

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.