ArticleVeterinary medicine and science2022
Detection of candidate genes affecting milk production traits in sheep using whole-genome sequencing analysis.
Article in Veterinary medicine and science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- A systematic review of hypervirulentFrontiers in medicine · 2025Pooled it
- From candidate genes to whole-genome approaches: current insights into the genetic architecture of ovine milk production and quality traits.Veterinary and animal science · 2026Review
- Putative Genomic Signatures of Local Adaptation in Five Local Indonesian Sheep Reveal Selection on Immunity, Reproduction, and Production Traits.Ecology and evolution · 2026Article
- Genomic analysis reveals convergent signatures of selection for milk traits in sheep and goats.Journal of animal science and biotechnology · 2026Article
- Genome-wide association study for Kleiber ratio and growth efficiency traits in Lori-Bakhtiari sheep.Tropical animal health and production · 2025Article
- Analysis of Population Structure and Selection Signatures in Two Iraqi Fat-Tailed Sheep Breeds.Veterinary medicine and science · 2025Article
- Article
- Associations Between Non-Steroidal and Steroidal Anti-Inflammatory Drug Use, Welfare, and Milk Production in Dairy Sheep: A Multivariate Study.Animals : an open access journal from MDPI · 2025Article
- Whole-Genome Resequencing in Sheep: Applications in Breeding, Evolution, and Conservation.Genes · 2025Review
- Genome-wide landscape of genetic diversity, runs of homozygosity, and runs of heterozygosity in five Alpine and Mediterranean goat breeds.Journal of animal science and biotechnology · 2025Article
- Revealing gene expression links between milk fat globules and mammary glands in rodents via transcriptomics.Frontiers in veterinary science · 2025Article
- Assessment of breeding nuclei contributions to the genetic diversity and population structure of the Cyprus Chios sheep.Scientific reports · 2024Article
- Whole genome resequencing-based analysis of plateau adaptation in Meiren yak (Animal biotechnology · 2024Article
- Host-microbe interaction-mediated resistance to DSS-induced inflammatory enteritis in sheep.Microbiome · 2024Article
- Whole Genome Scan Uncovers Candidate Genes Related to Milk Production Traits in Barka Cattle.International journal of molecular sciences · 2024Article
- Understanding Circular RNAs in Health, Welfare, and Productive Traits of Cattle, Goats, and Sheep.Animals : an open access journal from MDPI · 2024Review
- Pan-Omics in Sheep: Unveiling Genetic Landscapes.Animals : an open access journal from MDPI · 2024Review
- The implications of various gene variant combinations on breeding values for Awassi ewe milk production.Veterinary world · 2023Article
- Comparative genomic analysis uncovers candidate genes related with milk production and adaptive traits in goat breeds.Scientific reports · 2023Article
- The ovineFrontiers in veterinary science · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundArtificial and natural selection for important economic traits and genetic adaptation of the populations to specific environments have led to the changes on the sheep genome. Recent advances in genome sequencing methods have made it possible to use comparative genomics tools to identify genes under selection for traits of economic interest in domestic animals.
objectivesIn this study, we compared the genomes of Assaf and Awassi sheep breeds with those of the Cambridge, Romanov and British du cher sheep breeds to explore positive selection signatures for milk traits using nucleotide diversity (Pi) and FST statistical methods.
methodsGenome sequences from fourteen sheep with a mean sequence depth of 9.32X per sample were analysed, and a total of 23 million single nucleotide polymorphisms (SNPs) were called and applied for this study. Genomic clustering of breeds was identified using ADMIXTURE software. The FST and Pi values for each SNP were computed between population A (Assaf and Awassi) and population B (Cambridge, British du cher, and Romanov).
resultsThe results of the PCA grouped two classes for these five dairy sheep breeds. The selection signatures analysis displayed 735 and 515 genes from FST and nucleotide diversity (Pi) statistical methods, respectively. Among all these, 12 genes were shared between the two approaches. The most conspicuous genes were related to milk traits, including ST3GAL1 (the synthesis of oligosacáridos), CSN1S1 (milk protein), CSN2 (milk protein), OSBPL8 (fatty acid traits), SLC35A3 (milk fat and protein percentage), VPS13B (total milk production, fat yield, and protein yield), DPY19L1 (peak yield), CCDC152 (lactation persistency and somatic cell count), NT5DC1 (lactation persistency), P4HTM (test day protein), CYTH4 (FAT Production) and METRNL (somatic cell), U1 (milk traits), U6 (milk traits) and 5S_RRNA (milk traits).
conclusionsThe findings provide new insight into the genetic basis of sheep milk properties and can play a role in designing sheep breeding programs incorporating genomic information.
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