ArticleEuropean journal of heart failure2022
Quantified mitral regurgitation and left atrial function in heart failure with reduced ejection fraction: interplay and outcome implications.
Article in European journal of heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- Association of Left Atrial Function With Mitral Regurgitation: The Atherosclerosis Risk in Communities Study.Journal of the American Heart Association · 2025Observational
- 2024 update in heart failure.ESC heart failure · 2025Review
- Atrial Functional Mitral Regurgitation: From Diagnosis to Current Interventional Therapies.Journal of clinical medicine · 2024Review
- Incremental diagnostic and prognostic utility of left atrial deformation in heart failure using speckle tracking echocardiography.Heart failure reviews · 2024Review
- Left Atrium: A New Prognostic Marker and Therapeutic Target in Secondary Mitral Regurgitation?European cardiology · 2024Review
- Peak left atrial longitudinal strain is associated with all-cause mortality in patients with ventricular functional mitral regurgitation.Cardiovascular ultrasound · 2023Article
- Left atrial strain determinants and clinical features according to the heart failure stages. New insight from EACVI MASCOT registry.The international journal of cardiovascular imaging · 2022Observational
- Incremental prognostic value of left atrial strain in patients with heart failure.ESC heart failure · 2022Article
- The Role of the Left Atrium: From Multimodality Imaging to Clinical Practice: A Review.Life (Basel, Switzerland) · 2022Review
- Midterm Outcomes of Pediatric Mitral Valvuloplasty for Moderate to Severe Mitral Valve Regurgitation and Associated Risk Factors for Postoperative Deterioration.Texas Heart Institute journalArticle
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe clinical and prognostic importance of functional mitral regurgitation (FMR) in heart failure patients with reduced ejection fraction (HFrEF) has been highly debated. This study aims to define FMR linkage to cardiovascular (CV) outcomes and the interplay with left atrial (LA) function in a prospective cohort of consecutive HFrEF outpatients. METHODS AND
resultsOverall, 286 consecutive outpatients with chronic HFrEF were prospectively enrolled. FMR was quantified by effective regurgitant orifice area (EROA). Global peak atrial longitudinal strain (PALS) was measured by speckle tracking echocardiography. The primary endpoint was a composite of congestive heart failure hospitalization or CV death. During a mean follow-up of 4.1 ± 1.5 years, the primary endpoint occurred in 99 patients (35%). The spline modelling of the risk by FMR severity showed an excess event risk starting at about the EROA value of 0.1 cm
conclusionsOur results refine the independent association between FMR and CV outcome among HFrEF outpatients. Within a moderate EROA range, LA function mitigates the clinical consequences of mitral regurgitation, providing measurable proof of the interplay between regurgitation and LA compliance.
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