Evidence map›Paper›PMID 35014082›Full record

ArticleStatistics in medicine2022

B-value and empirical equivalence bound: A new procedure of hypothesis testing.

Yi Zhao, Brian S Caffo, Joshua B Ewen

Abstract read
In one paragraph

Article in Statistics in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yi ZhaoDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0003-4766-5934
Brian S CaffoDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Joshua B EwenKennedy Krieger Institute and Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Funding

Structural Biology CoreU54AG065181 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Kun Huang · 2019 to 2026
$61.3M
Research Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1M
Project-004U54DA049110 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Martin Lindquist, TOR D. WAGER · 2019 to 2026
$14.7M
S-nitrosylation signaling in asthmaP01HL158507 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN · 2021 to 2025
$12.0M
Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9M
Statistical methods for structural and functional integration in multi-modal neuroimaging dataR01EB029977 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI CAFFO, BRIAN SCOTT · 2021 to 2024
$1.9M
Direct Examination of Imitation-Based Learning in AutismR21NS091569 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI EWEN, JOSHUA B · 2015 to 2016
$444k
NHLBI NIH HHS P01 HL158507NIA NIH HHS P30 AG072976NIA NIH HHS U54 AG065181NIBIB NIH HHS R01 EB029977NICHD NIH HHS P50 HD103538NIDA NIH HHS U54 DA049110NINDS NIH HHS R21 NS091569
6 · The paper itself

Abstract

In this study, we propose a two-stage procedure for hypothesis testing, where the first stage is conventional hypothesis testing and the second is an equivalence testing procedure using an introduced empirical equivalence bound (EEB). In 2016, the American Statistical Association released a policy statement on P-values to clarify the proper use and interpretation in response to the criticism of reproducibility and replicability in scientific findings. A recent solution to improve reproducibility and transparency in statistical hypothesis testing is to integrate P-values (or confidence intervals) with practical or scientific significance. Similar ideas have been proposed via the equivalence test, where the goal is to infer equality under a presumption (null) of inequality of parameters. However, the definition of scientific significance/equivalence can sometimes be ill-justified and subjective. To circumvent this drawback, we introduce the B-value and the EEB, which are both estimated from the data. Performing a second-stage equivalence test, our procedure offers an opportunity to improve the reproducibility of findings across studies.

Indexed as

Research DesignHumansReproducibility of Resultsempirical equivalence boundequivalence testhypothesis testing

Identifiers

PMID35014082
PMCPMC8881334

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.