ArticleClinical cardiology2022
Proteomic differences among patients with heart failure taking furosemide or torsemide.
Article in Clinical cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Proteomics in Acute Heart Transplant Rejection, on Behalf of the GRAfT Investigators.Transplantation · 2025Article
- Torasemide Improves the Propionic Acid-Induced Autism in Rats: A Histopathological and Imaging Study.Alpha psychiatry · 2023Article
- Proteomic differences among patients with heart failure taking furosemide or torsemide.Clinical cardiology · 2022Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundLoop diuretics are commonly used for patients with heart failure (HF) but it remains unknown if one loop diuretic is clinically superior. HYPOTHESIS: Biomarkers and proteomics provide insight to how different loop diuretics may differentially affect outcomes.
methodsBlood and urine were collected from outpatients with HF who were taking torsemide or furosemide for >30 days. Differences were assessed in cardiac, renal, and inflammatory biomarkers and soluble protein panels using the Olink Cardiovascular III and inflammation panels.
resultsOf 78 subjects, 55 (71%) were treated with furosemide and 23 (29%) with torsemide, and 25 provided a urine sample (15 treated with furosemide, 10 with torsemide). Patients taking torsemide were older (68 vs 64 years) with a lower mean eGFR (46 vs 54 ml/min/1.73 m
conclusionsWe show differences in urinary biomarkers but few differences in plasma biomarkers among HF patients on different loop diuretics. Olink technology can detect differences in plasma protein levels from multiple biologic domains. These findings raise the importance of defining differences in mechanisms of action of each diuretic in an appropriately powered study.
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