Evidence map›Paper›PMID 35014027›Full record

ReviewActa anaesthesiologica Scandinavica2022

The role of mechanical ventilation in primary graft dysfunction in the postoperative lung transplant recipient: A single center study and literature review.

Anna Niroomand, Sara Qvarnström, Martin Stenlo, Malin Malmsjö, Richard Ingemansson, Snejana Hyllén, Sandra Lindstedt

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta anaesthesiologica Scandinavica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05526950 (Cytokine Filtration in Lung Transplantation - a Randomised, Controlled, Multicentre Clinical Trial), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05526950 narecruitingnot on this mapstarted 2023, after this paper: background citation

Cytokine Filtration in Lung Transplantation - a Randomised, Controlled, Multicentre Clinical Trial (GLUSorb)

TypeinterventionalSponsorLund University HospitalRan2023 to 2029Enrolled116ConditionsLung Transplant Failure, Lung Transplant, ComplicationsArmsDevice: CytoSorb
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Observational
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Anna NiroomandDepartment of Cardiothoracic Anesthesia and Intensive Care and Cardiothoracic Surgery and Transplantation, Skåne University Hospital, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0002-6402-9414
Sara QvarnströmDepartment of Cardiothoracic Anesthesia and Intensive Care and Cardiothoracic Surgery and Transplantation, Skåne University Hospital, Lund University, Lund, Sweden.
Martin StenloDepartment of Cardiothoracic Anesthesia and Intensive Care and Cardiothoracic Surgery and Transplantation, Skåne University Hospital, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0001-8328-259X
Malin MalmsjöDepartment of Clinical Sciences, Lund University, Lund, Sweden.
Richard IngemanssonDepartment of Cardiothoracic Anesthesia and Intensive Care and Cardiothoracic Surgery and Transplantation, Skåne University Hospital, Lund University, Lund, Sweden.
Snejana HyllénDepartment of Cardiothoracic Anesthesia and Intensive Care and Cardiothoracic Surgery and Transplantation, Skåne University Hospital, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0003-1253-4969
Sandra LindstedtDepartment of Cardiothoracic Anesthesia and Intensive Care and Cardiothoracic Surgery and Transplantation, Skåne University Hospital, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0003-4484-6473
Lund University · SERutgers, The State University of New Jersey · US

Funding

ALF FoundationWallenberg Molecular Medicine Fellowship
6 · The paper itself

Abstract

backgroundPrimary graft dysfunction (PGD) is still a major complication in patients undergoing lung transplantation (LTx). Much is unknown about the effect of postoperative mechanical ventilation on outcomes, with debate on the best approach to ventilation. AIM/PURPOSE: The goal of this study was to generate hypotheses on the association between postoperative mechanical ventilation settings and allograft size matching in PGD development.

methodThis is a retrospective study of LTx patients between September 2011 and September 2018 (n = 116). PGD was assessed according to the International Society of Heart and Lung Transplantation (ISHLT) criteria. Data were collected from medical records, including chest x-ray assessments, blood gas analysis, mechanical ventilator parameters and spirometry.

resultsPositive end-expiratory pressures (PEEP) of 5 cm H

conclusionOur results highlight a need for greater investigation of the role donor characteristics play in determining post-operative ventilation of a lung transplant recipient. The mechanical ventilation settings on postoperative LTx recipients may have an implication for the development of acute graft dysfunction. Severe PGD was associated with the use of a PEEP higher than 5 and lower tidal volumes and oversized lungs were associated with lower long-term mortality. Lack of association between ventilatory settings and survival may point to the importance of other variables than ventilation in the development of PGD.

Indexed as

Lung TransplantationPrimary Graft DysfunctionHumansLungRespiration, ArtificialRetrospective StudiesRisk FactorsTransplant Recipientslung transplant recipientspostoperative mechanical ventilationprimary graft dysfunctionprotective lung ventilation

Identifiers

PMID35014027
PMCPMC9303877
OpenAlexW4206802569

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.