Evidence map›Paper›PMID 35013519›Full record

ArticleCommunications biology2022

Adenosine 2A receptor and TIM3 suppress cytolytic killing of tumor cells via cytoskeletal polarization.

Grace L Edmunds, Carissa C W Wong, Rachel Ambler, Emily J Milodowski, Hanin Alamir, Stephen J Cross, Gabriella Galea, Christoph Wülfing, David J Morgan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Grace L EdmundsSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK.
Carissa C W WongSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK.
Rachel AmblerSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK.
Emily J MilodowskiBristol Veterinary School, University of Bristol, Bristol, BS40 5DU, UK.
Hanin AlamirSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK.
Stephen J CrossWolfson BioImaging Facility, University of Bristol, Bristol, BS8 1TD, UK.ORCID 0000-0003-3565-0479
Gabriella GaleaSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK.ORCID 0000-0002-0928-7226
Christoph WülfingSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK. Christoph.Wuelfing@bristol.ac.uk.ORCID 0000-0002-6156-9861
David J MorganSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK. D.J.Morgan@bristol.ac.uk.ORCID 0000-0001-9896-0437
University of Bristol · GBAt Bristol · GB

Funding

RCUK | Medical Research Council (MRC) GW4 DTPWellcome TrustWellcome Trust (Wellcome) 102387/Z/13/Z/Wellcome Trust (Wellcome) 105612/Z/14/ZWellcome Trust (Wellcome) 201254/Z/16/Z/Wellcome Trust (Wellcome) GW4-CAT
6 · The paper itself

Abstract

Tumors generate an immune-suppressive environment that prevents effective killing of tumor cells by CD8

Indexed as

Cell DeathAdenosine A2 Receptor AgonistsAnimalsCell Line, TumorCytoskeletonCytosolFemaleHepatitis A Virus Cellular Receptor 2MaleMiceMice, Inbred BALB CReceptor, Adenosine A2AAdenosine A2 Receptor AgonistsAdora2a protein, mouseHavcr2 protein, mouseHepatitis A Virus Cellular Receptor 2Receptor, Adenosine A2A

Identifiers

PMID35013519
PMCPMC8748690
OpenAlexW4206077930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.