ArticleClinical and experimental immunology1987
Family study of the major histocompatibility complex in HLA DR3 negative patients with systemic lupus erythematosus.
Article in Clinical and experimental immunology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 50 citations in OpenAlex.
- Across ancestries, HLA-B∗08:01∼DRB1∗03:01 (DR3) and HLA-DQA∗01:02 (DR2) increase the risk to develop juvenile-onset systemic lupus erythematosus through low complement C4 levels.Journal of translational autoimmunity · 2025Article
- Correlation of ESR, C3, C4, anti-DNA and lupus activity based on British Isles Lupus Assessment Group Index in patients of rheumatology clinic.Rheumatology international · 2010Article
- British Isles Lupus Assessment Group 2004 index is valid for assessment of disease activity in systemic lupus erythematosus.Arthritis and rheumatism · 2007Article
- Identification of two independent risk factors for lupus within the MHC in United Kingdom families.PLoS genetics · 2007Article
- Genetic bases of autoimmune hepatitis.Digestive diseases and sciences · 2002Review
- Quantitative analysis of C4Ab and C4Bb binding to the C3b/C4b receptor (CR1, CD35).Clinical and experimental immunology · 1997Article
- HLA-DP does not contribute towards susceptibility to systemic lupus erythematosus.Annals of the rheumatic diseases · 1994Article
- Differential contribution of C4 and HLA-DQ genes to systemic lupus erythematosus susceptibility.Human genetics · 1993Article
- Complement and glomerulonephritis--an update.Pediatric nephrology (Berlin, Germany) · 1993Review
- Major histocompatibility complex haplotypes and complement C4 alleles in systemic lupus erythematosus. Results of a multicenter study.The Journal of clinical investigation · 1992Article
- Selective IgA deficiency associated with glomerulonephritis and oligoarthritis.Annals of the rheumatic diseases · 1992Article
- Influence of C4 null alleles on C4 activation in systemic lupus erythematosus.Annals of the rheumatic diseases · 1991Article
- C4 null alleles in childhood onset systemic lupus erythematosus. Is there any relationship with renal disease?Pediatric nephrology (Berlin, Germany) · 1990Article
- Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Susceptibility to systemic lupus erythematosus (SLE) is known to be governed by genes in the HLA region of the 6th chromosome. From previous studies it has not been possible to distinguish between the effects of null genes for the complement component C4 and HLA-DR3, because of the marked linkage disequilibrium between DR3 and a null allele of C4A (C4A QO) in caucasoid populations. We report here an immunogenetic study of 44 cases of SLE, selected because they were DR3 negative. Eighteen of the 30 Caucasoid cases (60%) had extended HLA haplotypes with a C4 null allele, compared with 22 of 60 (37%) of a control panel of 60 DR3 negative normal Caucasoid subjects. This difference is significant (chi 2 = 4.41; 0.05 greater than P greater than 0.01). Of 14 non-caucasoid patients analysed, 10 had a C4 null allele. It is concluded that the null alleles of the C4 A and B genes are themselves directly responsible for conferring susceptibility to SLE.
Indexed as
Identifiers
3501348PMC1542102W216931163What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.