Evidence map›Paper›PMID 35013474›Full record

ArticleNature communications2022

Guest-host doped strategy for constructing ultralong-lifetime near-infrared organic phosphorescence materials for bioimaging.

Fuming Xiao, Heqi Gao, Yunxiang Lei, Wenbo Dai, Miaochang Liu, Xiaoyan Zheng, Zhengxu Cai, Xiaobo Huang, Huayue Wu, Dan Ding

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed.

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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fuming Xiao *School of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
Heqi Gao *State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, and College of Life Sciences, Nankai University, Tianjin, 300071, China.
Yunxiang LeiSchool of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China. yunxianglei@wzu.edu.cn.
Wenbo DaiSchool of Materials Science & Engineering, Beijing Institute of Technology, Beijing, 10081, P. R. China.
Miaochang LiuSchool of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
Xiaoyan ZhengSchool of Materials Science & Engineering, Beijing Institute of Technology, Beijing, 10081, P. R. China.ORCID http://orcid.org/0000-0002-6584-9596
Zhengxu CaiSchool of Materials Science & Engineering, Beijing Institute of Technology, Beijing, 10081, P. R. China.ORCID http://orcid.org/0000-0003-0239-9601
Xiaobo HuangSchool of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China. xiaobhuang@wzu.edu.cn.
Huayue WuSchool of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
Dan DingState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, and College of Life Sciences, Nankai University, Tianjin, 300071, China. dingd@nankai.edu.cn.ORCID http://orcid.org/0000-0003-1873-6510

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organic near-infrared room temperature phosphorescence materials have unparalleled advantages in bioimaging due to their excellent penetrability. However, limited by the energy gap law, the near-infrared phosphorescence materials (>650 nm) are very rare, moreover, the phosphorescence lifetimes of these materials are very short. In this work, we have obtained organic room temperature phosphorescence materials with long wavelengths (600/657-681/732 nm) and long lifetimes (102-324 ms) for the first time through the guest-host doped strategy. The guest molecule has sufficient conjugation to reduce the lowest triplet energy level and the host assists the guest in exciton transfer and inhibits the non-radiative transition of guest excitons. These materials exhibit good tissue penetration in bioimaging. Thanks to the characteristic of long lifetime and long wavelength emissive phosphorescence materials, the tumor imaging in living mice with a signal to background ratio value as high as 43 is successfully realized. This work provides a practical solution for the construction of organic phosphorescence materials with both long wavelengths and long lifetimes.

Indexed as

AnimalsBenzophenonesFluorescent DyesLuminescent AgentsLymph NodesMiceNanoparticlesNeoplasmsOptical ImagingPyrenesPyridinesSpectroscopy, Near-Infrared1-bromopyrenebenzophenoneBenzophenonesFluorescent DyesLuminescent AgentsPyrenesPyridines

Identifiers

PMID35013474
PMCPMC8748955

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.