ArticleNPJ Parkinson's disease2022
Functional connectivity in Parkinson's disease candidates for deep brain stimulation.
Article in NPJ Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Personalized high-intensity temporal interference stimulation decouples cerebellar networks to enhance implicit learning.Journal of neuroengineering and rehabilitation · 2026Trial
- Multimodal brain network topology and enhanced computer-aided diagnosis in Parkinson's Disease: a systematic review and meta-analysis.NPJ digital medicine · 2026Article
- Three-Dimensional Point-Cloud Learning for Patient-Specific Deep Brain Stimulation Motor Response Prediction in Parkinson Disease.BME frontiers · 2026Article
- Considerations for conducting developmental neuroimaging research on mental health topics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Preoperative Functional Connectivity Predicts Antiparkinson Drug Change after Deep Brain Stimulation.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Two-year longitudinal neuropsychological monitoring after unilateral and staged bilateral subthalamic nucleus deep brain stimulation.Frontiers in neuroscience · 2026Article
- Disuse-driven plasticity in the human thalamus and putamen.Cell reports · 2025Article
- Electrophysiological Alterations in the Progression of Parkinson's Disease and the Therapeutic Effect of Tetrabenazine on Rats With Levodopa-Induced Dyskinesia.CNS neuroscience & therapeutics · 2025Article
- Revealing connectivity patterns of deep brain stimulation efficacy in Parkinson's disease.Scientific reports · 2024Article
- Push-pull effects of basal ganglia network in Parkinson's disease inferred by functional MRI.NPJ Parkinson's disease · 2024Article
- Acoustic assessment in mandarin-speaking Parkinson's disease patients and disease progression monitoring and brain impairment within the speech subsystem.NPJ Parkinson's disease · 2024Review
- Disuse-driven plasticity in the human thalamus and putamen.bioRxiv : the preprint server for biology · 2024Article
- Functional brain controllability in Parkinson's disease and its association with motor outcomes after deep brain stimulation.Frontiers in neuroscience · 2024Article
- Exploring the application and challenges of fNIRS technology in early detection of Parkinson's disease.Frontiers in aging neuroscience · 2024Article
- PET, SPECT, and MRI imaging for evaluation of Parkinson's disease.American journal of nuclear medicine and molecular imaging · 2024Review
- Eltoprazine modulated gamma oscillations on ameliorating L-dopa-induced dyskinesia in rats.CNS neuroscience & therapeutics · 2023Article
- Longitudinal brain functional connectivity changes induced by neurosurgical thalamotomy for tremor in Parkinson's disease: a preliminary study.Journal of neurology · 2023Article
- Connectivity Analysis in EEG Data: A Tutorial Review of the State of the Art and Emerging Trends.Bioengineering (Basel, Switzerland) · 2023Review
- Altered Functional Connectivity of the Subthalamic Nucleus in Parkinson's Disease: Focus on Candidates for Deep Brain Stimulation.Journal of Parkinson's disease · 2023Article
- Predicting age from resting-state scalp EEG signals with deep convolutional neural networks on TD-brain dataset.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
This study aimed to identify functional neuroimaging patterns anticipating the clinical indication for deep brain stimulation (DBS) in patients with Parkinson's disease (PD). A cohort of prospectively recruited patients with PD underwent neurological evaluations and resting-state functional MRI (RS-fMRI) at baseline and annually for 4 years. Patients were divided into two groups: 19 patients eligible for DBS over the follow-up and 41 patients who did not meet the criteria to undergo DBS. Patients selected as candidates for DBS did not undergo surgery at this stage. Sixty age- and sex-matched healthy controls performed baseline evaluations. Graph analysis and connectomics assessed global and local topological network properties and regional functional connectivity at baseline and at each time point. At baseline, network analysis showed a higher mean nodal strength, local efficiency, and clustering coefficient of the occipital areas in candidates for DBS over time relative to controls and patients not eligible for DBS. The occipital hyperconnectivity pattern was confirmed by regional analysis. At baseline, a decreased functional connectivity between basal ganglia and sensorimotor/frontal networks was found in candidates for DBS compared to patients not eligible for surgery. In the longitudinal analysis, patient candidate for DBS showed a progressively decreased topological brain organization and functional connectivity, mainly in the posterior brain networks, and a progressively increased connectivity of basal ganglia network compared to non-candidates for DBS. RS-fMRI may support the clinical indication to DBS and could be useful in predicting which patients would be eligible for DBS in the earlier stages of PD.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.