Evidence map›Paper›PMID 35013320›Full record

ArticleNPJ Regenerative medicine2022

Esophageal regeneration following surgical implantation of a tissue engineered esophageal implant in a pediatric model.

Sumati Sundaram, Todd Jensen, Tina Roffidal, Karissa Paquin, Heather Wanczyk, Michael D Cockman, Shawyon Shadman, Christine Finck, William Fodor

Abstract read
In one paragraph

Article in NPJ Regenerative medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Esophagus engineering tackles function.Nature biotechnology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sumati Sundaram *Biostage, 84 October Hill Rd., Holliston, MA, 01746, USA.
Todd Jensen *Department of Pediatrics, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT, 06030, USA.
Tina RoffidalBiostage, 84 October Hill Rd., Holliston, MA, 01746, USA.
Karissa PaquinBiostage, 84 October Hill Rd., Holliston, MA, 01746, USA.
Heather WanczykDepartment of Pediatrics, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT, 06030, USA.
Michael D CockmanMedical Metrics, Inc., Suite 300, 2121 Sage Rd., Houston, TX, 77056, USA.
Shawyon ShadmanMadison Radiologists, 1221 John Q Hammons Dr., Madison, WI, 53725, USA.
Christine FinckDepartment of Pediatrics, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT, 06030, USA. cfinck@connecticutchildrens.org.
William FodorBiostage, 84 October Hill Rd., Holliston, MA, 01746, USA. wfodor@biostage.com.ORCID http://orcid.org/0000-0001-8616-4425

Funding

A retrievable autologous bioengineered esophageal implant as a novel treatment for long-gap esophageal atresiaR44HD095784 · NICHD · BIOSTAGE, INC. · PI FINCK, CHRISTINE M, FODOR, WILLIAM L · 2018 to 2020
$1.8M
NICHD NIH HHS R44 HD095784U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R44 Grant R44HD095784U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R44HD095784
6 · The paper itself

Abstract

Diseases of the esophagus, damage of the esophagus due to injury or congenital defects during fetal esophageal development, i.e., esophageal atresia (EA), typically require surgical intervention to restore esophageal continuity. The development of tissue engineered tubular structures would improve the treatment options for these conditions by providing an alternative that is organ sparing and can be manufactured to fit the exact dimensions of the defect. An autologous tissue engineered Cellspan Esophageal Implant

Identifiers

PMID35013320
PMCPMC8748753

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.