Evidence map›Paper›PMID 35013273›Full record

SynthesisNature communications2022

Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis.

Markus Scholz, Katrin Horn, Janne Pott, Arnd Gross, Marcus E Kleber, Graciela E Delgado, Pashupati Prasad Mishra, Holger Kirsten, Christian Gieger, Martina Müller-Nurasyid and 16 more

Erratum issuedOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 11 institutions in 3 countries.

Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany. markus.scholz@imise.uni-leipzig.de.ORCID http://orcid.org/0000-0002-4059-1779
Katrin HornInstitute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-5307-6936
Janne PottInstitute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-5983-5331
Arnd GrossInstitute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-5961-5507
Marcus E KleberMedical Faculty Mannheim, Vth Department of Medicine, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-0663-7275
Graciela E DelgadoMedical Faculty Mannheim, Vth Department of Medicine, Heidelberg University, Heidelberg, Germany.
Pashupati Prasad MishraDepartment of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland.ORCID http://orcid.org/0000-0001-5177-3431
Holger KirstenInstitute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-3126-7950
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.ORCID http://orcid.org/0000-0001-6986-9554
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764, Neuherberg, Germany.
Anke TönjesMedical Department III - Endocrinology, Nephrology, Rheumatology, University Hospital Leipzig, Leipzig, Germany.
Peter KovacsGerman Center for Diabetes Research (DZD), Munich, Germany.ORCID http://orcid.org/0000-0002-0290-5423
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland.ORCID http://orcid.org/0000-0002-2555-4427
Olli RaitakariDepartment of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33521, Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33521, Finland.
Helena GyllingHeart and Lung Center, Cardiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Ronny BaberLIFE Research Center for Civilization Diseases, Medical Faculty, University of Leipzig, Leipzig, Germany.
Berend IsermannInstitute for Laboratory Medicine Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.
Michael StumvollMedical Department III - Endocrinology, Nephrology, Rheumatology, University Hospital Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0001-6225-8240
Markus LoefflerInstitute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany.
Winfried MärzMedical Faculty Mannheim, Vth Department of Medicine, Heidelberg University, Heidelberg, Germany.
Thomas MeitingerInstitue for Human Genetics, Technical University of Munich, Munich, Germany.
Annette PetersInstitue of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.ORCID http://orcid.org/0000-0001-6645-0985
Joachim ThieryLIFE Research Center for Civilization Diseases, Medical Faculty, University of Leipzig, Leipzig, Germany.
Daniel TeupserInsitute for Laboratory Medicine, Ludwig-Maximilians University of Munich, Munich, Germany.
Uta CeglarekLIFE Research Center for Civilization Diseases, Medical Faculty, University of Leipzig, Leipzig, Germany.
University Hospital Leipzig · DELeipzig University · DEHeidelberg University · DEHelmholtz Zentrum München · DETampere University · FITampere University Hospital · FIJohannes Gutenberg University Mainz · DELudwig-Maximilians-Universität München · DEMedical University of Graz · ATTechnical University of Munich · DEUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phytosterol serum concentrations are under tight genetic control. The relationship between phytosterols and coronary artery disease (CAD) is controversially discussed. We perform a genome-wide meta-analysis of 32 phytosterol traits reflecting resorption, cholesterol synthesis and esterification in six studies with up to 9758 subjects and detect ten independent genome-wide significant SNPs at seven genomic loci. We confirm previously established associations at ABCG5/8 and ABO and demonstrate an extended locus heterogeneity at ABCG5/8 with different functional mechanisms. New loci comprise HMGCR, NPC1L1, PNLIPRP2, SCARB1 and APOE. Based on these results, we perform Mendelian Randomization analyses (MR) revealing a risk-increasing causal relationship of sitosterol serum concentrations and CAD, which is partly mediated by cholesterol. Here we report that phytosterols are polygenic traits. MR add evidence of both, direct and indirect causal effects of sitosterol on CAD.

Indexed as

Genetic LociABO Blood-Group SystemAdultApolipoproteins EATP Binding Cassette Transporter, Subfamily G, Member 5ATP Binding Cassette Transporter, Subfamily G, Member 8CholesterolCoronary Artery DiseaseFemaleGene Expression RegulationGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansHydroxymethylglutaryl CoA ReductasesLipaseLipid MetabolismABCG5 protein, humanABCG8 protein, humanABO Blood-Group SystemApoE protein, humanApolipoproteins EATP Binding Cassette Transporter, Subfamily G, Member 5ATP Binding Cassette Transporter, Subfamily G, Member 8CholesterolHMGCR protein, humanHydroxymethylglutaryl CoA ReductasesLipaseLipoproteinsMembrane Transport ProteinsNPC1L1 protein, humanPhytosterolsPNLIP protein, humanSCARB1 protein, humanScavenger Receptors, Class B

Identifiers

PMID35013273
PMCPMC8748632
OpenAlexW4206363150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.