SynthesisNature communications2022
DNA methylation aging and transcriptomic studies in horses.
Synthesis in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
30 citing papers in PubMed, 51 citations in OpenAlex.
- The Evolving Landscape of Clinical Aging Clocks: From Epigenetic to Multi-Omics Integration.Aging cell · 2026Review
- Equine models in translational medicine: A comparative approach to human health.Animal models and experimental medicine · 2026Review
- Integrative epigenetics and transcriptomics identify aging genes in human blood.Nature communications · 2026Article
- Review: Genomic insights into the adaptive traits and stress resistance in modern horses.Stress biology · 2026Review
- CMImpute: cross-species and tissue imputation of species-level DNA methylation samples across mammalian species.Genome biology · 2025Article
- The androgen clock is an epigenetic predictor of long-term male hormone exposure.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- In search of epigenetic hallmarks of different tissues: an integrative omics study of horse liver, lung, and heart.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- Unraveling the DNA methylation landscape in dog blood across breeds.BMC genomics · 2024Article
- Identification of DNA methylation markers for age and Bovine Respiratory Disease in dairy cattle: A pilot study based on Reduced Representation Bisulfite Sequencing.Communications biology · 2024Article
- Review
- Pan-primate studies of age and sex.GeroScience · 2023Article
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- Article
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- Getting the chronological age out of DNA: using insights of age-dependent DNA methylation for forensic DNA applications.Genes & genomics · 2023Review
- The localization of centromere protein A is conserved among tissues.Communications biology · 2023Article
- Universal DNA methylation age across mammalian tissues.Nature aging · 2023Article
- DNA methylation networks underlying mammalian traits.Science (New York, N.Y.) · 2023Article
- Harnessing male germline epigenomics for the genetic improvement in cattle.Journal of animal science and biotechnology · 2023Review
- A comparison of feature selection methodologies and learning algorithms in the development of a DNA methylation-based telomere length estimator.BMC bioinformatics · 2023Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Cytosine methylation patterns have not yet been thoroughly studied in horses. Here, we profile n = 333 samples from 42 horse tissue types at loci that are highly conserved between mammalian species using a custom array (HorvathMammalMethylChip40). Using the blood and liver tissues from horses, we develop five epigenetic aging clocks: a multi-tissue clock, a blood clock, a liver clock and two dual-species clocks that apply to both horses and humans. In addition, using blood methylation data from three additional equid species (plains zebra, Grevy's zebras and Somali asses), we develop another clock that applies across all equid species. Castration does not significantly impact the epigenetic aging rate of blood or liver samples from horses. Methylation and RNA data from the same tissues define the relationship between methylation and RNA expression across horse tissues. We expect that the multi-tissue atlas will become a valuable resource.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.