ArticleNature communications2022
Dynamics and mechanism of dimer dissociation of photoreceptor UVR8.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Phosphorylation of the plant photoreceptor UVR8 regulates its dimer/monomer status and enhances UV-B signaling across species.The Plant cell · 2026Article
- UVR8-mediated UV-B signaling and its regulation of horticultural traits: from Arabidopsis to application.Horticulture research · 2026Review
- Electron Transport through a Tryptophan Quadruplex in a Dimeric Azurin Construct.The journal of physical chemistry. B · 2026Article
- Recent advances in UV-B signalling: interaction of proteins with the UVR8 photoreceptor.Journal of experimental botany · 2025Review
- Sensing a rainbow of colors: algal photoreceptors.Frontiers in plant science · 2025Review
- How Histone Acetyltransferases Shape Plant Photomorphogenesis and UV Response.International journal of molecular sciences · 2024Review
- Ultraviolet Superradiance from Mega-Networks of Tryptophan in Biological Architectures.The journal of physical chemistry. B · 2024Article
- Phosphorylation of Arabidopsis UVR8 photoreceptor modulates protein interactions and responses to UV-B radiation.Nature communications · 2024Article
- Review
- Excimer Energies.The journal of physical chemistry letters · 2023Article
- RUP2 facilitates UVR8 redimerization via two interfaces.Plant communications · 2023Article
- Functions of nitric oxide-mediated post-translational modifications under abiotic stress.Frontiers in plant science · 2023Review
- Mechanisms of UV-B light-induced photoreceptor UVR8 nuclear localization dynamics.The New phytologist · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Photoreceptors are a class of light-sensing proteins with critical biological functions. UVR8 is the only identified UV photoreceptor in plants and its dimer dissociation upon UV sensing activates UV-protective processes. However, the dissociation mechanism is still poorly understood. Here, by integrating extensive mutations, ultrafast spectroscopy, and computational calculations, we find that the funneled excitation energy in the interfacial tryptophan (Trp) pyramid center drives a directional Trp-Trp charge separation in 80 ps and produces a critical transient Trp anion, enabling its ultrafast charge neutralization with a nearby positive arginine residue in 17 ps to destroy a key salt bridge. A domino effect is then triggered to unzip the strong interfacial interactions, which is facilitated through flooding the interface by channel and interfacial water molecules. These detailed dynamics reveal a unique molecular mechanism of UV-induced dimer monomerization.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.