ArticleNature communications2022
Prefrontal cortical plasticity during learning of cognitive tasks.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- The two-back task leads to activity in the left dorsolateral prefrontal cortex in schizophrenia patients with predominant negative symptoms: a fNIRS study and its implication for tDCS.Experimental brain research · 2024Trial
- Active Ingredients in Digital Cognitive Interventions: Integrating Dismantling Designs With Mechanistic Neuroscience.JMIR mental health · 2026Article
- Long-term Learning Induces Plastic Changes in Frontostriatal Circuits.bioRxiv : the preprint server for biology · 2026Article
- Prefrontal Mechanisms of Rule Learning.bioRxiv : the preprint server for biology · 2026Article
- Intracortical Microstimulation in Brain-Computer Interfaces: Evoking Perception and Plasticity.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- Mitigating organophosphate nerve agent, soman (GD), induced long-term neurotoxicity: Saracatinib, a Src Tyrosine Kinase inhibitor, as a potential countermeasure.Journal of neuroinflammation · 2025Article
- Transferable Modulation of Cognitive Control: The Cross-Task Role of Conflict Adaptation in Thematic Roles Assignment in Chinese.Behavioral sciences (Basel, Switzerland) · 2025Article
- GPR43 regulates mitochondrial apoptosis through the cyclophilin D pathway in Alzheimer's disease.Molecular medicine (Cambridge, Mass.) · 2025Article
- Unraveling the roles of spatial working memory sustained and selective neurons in prefrontal cortex.Communications biology · 2025Article
- Functional role of cell classes in monkey prefrontal cortex after learning a working memory task.Communications biology · 2025Article
- Alzheimer's disease and other memory disorders in the age of AI: reflection and perspectives on the 120th anniversary of the birth of Dr. John von Neumann.GeroScience · 2025Review
- Compositional architecture: Orthogonal neural codes for task context and spatial memory in prefrontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Neural signatures of engagement in driving: comparing active control and passive observation.Frontiers in neuroscience · 2025Article
- Ventral frontostriatal circuitry mediates the computation of reinforcement from symbolic gains and losses.Neuron · 2024Article
- Is working memory domain-general or domain-specific?Trends in cognitive sciences · 2024Review
- Timescales of learning in prefrontal cortex.Nature reviews. Neuroscience · 2024Review
- Delta-alpha/beta coupling as a signature of visual working memory in the prefrontal cortex.iScience · 2024Article
- A Systematic Review and Narrative Synthesis of Cognitive Training in the Treatment of Mental Illness and Substance Use Disorder.Journal of clinical medicine · 2024Review
- Changes in brain structure and function during early aging in patients with chronic low back pain.Frontiers in aging neuroscience · 2024Article
- Common Mechanisms of Learning in Motor and Cognitive Systems.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Training in working memory tasks is associated with lasting changes in prefrontal cortical activity. To assess the neural activity changes induced by training, we recorded single units, multi-unit activity (MUA) and local field potentials (LFP) with chronic electrode arrays implanted in the prefrontal cortex of two monkeys, throughout the period they were trained to perform cognitive tasks. Mastering different task phases was associated with distinct changes in neural activity, which included recruitment of larger numbers of neurons, increases or decreases of their firing rate, changes in the correlation structure between neurons, and redistribution of power across LFP frequency bands. In every training phase, changes induced by the actively learned task were also observed in a control task, which remained the same across the training period. Our results reveal how learning to perform cognitive tasks induces plasticity of prefrontal cortical activity, and how activity changes may generalize between tasks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.