ArticleNature communications2022
Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology.
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In one paragraph
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 2 pooled it
26.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
143 citing papers in PubMed, 2 syntheses or guidelines pooled it, 225 citations in OpenAlex.
- Blood Astrocyte Biomarkers in Alzheimer Disease: A Systematic Review and Meta-Analysis.Neurology · 2024Pooled it
- The impact of physical exercise on neuroinflammation mechanism in Alzheimer's disease.Frontiers in aging neuroscience · 2024Pooled it
- Multi-Component Xinjiang Basil Essential Oil Mitigates Alzheimer's Disease-like Pathology Through Amyloid and Neuroinflammatory Modulation.Nutrients · 2026Article
- Molecular programs in human locus coeruleus link APOE and neuromelanin to Alzheimer's vulnerability.Acta neuropathologica · 2026Article
- Neuroinflammatory suppression of astrocytic BMAL1 defines a selective reactive astrocyte program.Journal of neuroinflammation · 2026Article
- ThebioRxiv : the preprint server for biology · 2026Article
- Sex-specific associations between astrocytic reactivity and cognitive decline in unimpaired elderly.bioRxiv : the preprint server for biology · 2026Article
- Long-term real-world PM 2.5 exposure induces depression-like behaviors in mice by disrupting nuclear factor erythroid 2-related factor 2-mediated astrocyte-to-microglia communication.Neural regeneration research · 2026Article
- PINK1 loss in astrocytes triggers inflammatory dysfunction and neuronal death.bioRxiv : the preprint server for biology · 2026Article
- Neuronal overexpression of Nrf2 reduces dystrophic neurites in 5XFAD Alzheimer's disease model mice.Alzheimer's research & therapy · 2026Article
- Targeting MAPK-dependent pathways to modulate reactive astrocyte pathology in neurodegeneration.Communications biology · 2026Article
- Inhibition of endocannabinoid degradation in astrocytes reprograms glial reactivity and prevents seizure sequelae.Journal of neuroinflammation · 2026Article
- Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease.The European journal of neuroscience · 2026Review
- Complex interplay of astrogliosis and pathology in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Glial pathology networks reveal early olfactory vulnerability in post mortem human Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Astrocyte Proximity Protects Synapses From Human Amyloid-Beta Induced Degeneration in a Mouse Ex Vivo Model of Early Alzheimer's Disease.The European journal of neuroscience · 2026Article
- Neuronal overexpression of Nrf2 reduces dystrophic neurites in 5XFAD Alzheimer's disease model mice.bioRxiv : the preprint server for biology · 2026Article
- Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation.Neurology international · 2026Review
- REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Early astrocyte-targeted intervention guided byEuropean journal of nuclear medicine and molecular imaging · 2026Article
83 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 4 institutions in 2 countries.
Zoeb Jiwaji *UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.ORCID http://orcid.org/0000-0002-3129-1168
Sachin S Tiwari *UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.
Rolando X Avilés-Reyes *Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA.
Monique Hooley *UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.
David HamptonUK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.
Megan TorvellUK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.ORCID http://orcid.org/0000-0003-3789-1452
Delinda A JohnsonDivision of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA.
Jamie McQueenUK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.ORCID http://orcid.org/0000-0001-7172-7504
Paul BaxterUK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.
Kayalvizhi Sabari-SankarDivision of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA.
Jing QiuUK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.
Xin HeUK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.
Jill FowlerCentre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK.
James FeberyCentre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK.
Jenna GregoryUK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.ORCID http://orcid.org/0000-0003-3337-4079
Jamie RoseUK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.
Jane TullochUK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.
Jamie LoanUK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.ORCID http://orcid.org/0000-0002-6451-9448
David StoryUK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.
Karina McDadeUK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.
Amy M SmithUK Dementia Research Institute at Imperial College, Burlington Danes Building, Hammersmith Hospital, London, W12 0NN, UK.
Peta GreerUK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.
Matthew BallUK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.
Peter C KindUK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.
Paul M MatthewsUK Dementia Research Institute at Imperial College, Burlington Danes Building, Hammersmith Hospital, London, W12 0NN, UK.ORCID http://orcid.org/0000-0002-1619-8328
Colin SmithCentre for Clinical Brain Sciences, University of Edinburgh Chancellor's Building, Edinburgh, UK.
Owen DandoUK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.ORCID http://orcid.org/0000-0002-6269-6408
Tara L Spires-JonesUK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.ORCID http://orcid.org/0000-0003-2530-0598
Jeffrey A JohnsonDivision of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA. jeffrey.johnson@wisc.edu.ORCID http://orcid.org/0000-0002-3315-7210
Siddharthan ChandranUK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK. Siddharthan.Chandran@ed.ac.uk.
Giles E HardinghamUK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK. Giles.Hardingham@ed.ac.uk.ORCID http://orcid.org/0000-0002-7629-5314
UK Dementia Research Institute · GBUniversity of Wisconsin–Madison · USUniversity of Edinburgh · GBHammersmith Hospital · GB
Funding
Wisconsin Alzheimer's Disease Research CenterP50AG033514 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI SAGER, MARK · 2009 to 2018
$16.2MChief Scientist Office PCL/20/05Medical Research Council MC_EX_MR/N50192X/1Medical Research Council MC_PC_17113Medical Research Council MR/N013255/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/N001419/1NIA NIH HHS P50 AG033514
Abstract
Alzheimer's disease (AD) alters astrocytes, but the effect of Aß and Tau pathology is poorly understood. TRAP-seq translatome analysis of astrocytes in APP/PS1 ß-amyloidopathy and MAPT
Indexed as
Alzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsAstrocytesBrainDisease Models, AnimalFemaleGene Expression ProfilingGene Expression RegulationHomozygoteHumansMiceMice, TransgenicNeuroprotectionNF-E2-Related Factor 2PhenotypeAmyloid beta-Protein PrecursorAPP protein, mouseMapt protein, mouseNfe2l2 protein, mouseNF-E2-Related Factor 2Proto-Oncogene ProteinsProto-Oncogene Protein Spi-1tau ProteinsTrans-Activators
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.