ArticleNature communications2022
Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- A Simple Mammalian Whole Embryo Culture System to Study High-Temperature Effects on Development.Acta histochemica et cytochemica · 2026Article
- Dynamic remodeling of membrane proteins for temperature adaptation in oysters.Zoological research · 2026Article
- Comprehensive comparative analysis of the effects of temperature on the Notch signaling response in vivo.Biology open · 2025Article
- Oscillatory DeltaC Expression in Neural Progenitors Primes the Prototype of Forebrain Development.Molecular neurobiology · 2025Article
- Intracellular pH differentially regulates transcription of metabolic and signaling pathways in normal epithelial cells.The Journal of biological chemistry · 2024Article
- Notch1 Phase Separation Coupled Percolation facilitates target gene expression and enhancer looping.Scientific reports · 2024Article
- Notch1 Phase Separation Coupled Percolation facilitates target gene expression and enhancer looping.bioRxiv : the preprint server for biology · 2024Article
- Neural differentiation in perspective: mitochondria as early programmers.Frontiers in neuroscience · 2024Review
- Regulation of immune cell development, differentiation and function by stromal Notch ligands.Current opinion in cell biology · 2023Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ambient temperature significantly affects developmental timing in animals. The temperature sensitivity of embryogenesis is generally believed to be a consequence of the thermal dependency of cellular metabolism. However, the adaptive molecular mechanisms that respond to variations in temperature remain unclear. Here, we report species-specific thermal sensitivity of Notch signaling in the developing amniote brain. Transient hypothermic conditions increase canonical Notch activity and reduce neurogenesis in chick neural progenitors. Increased biosynthesis of phosphatidylethanolamine, a major glycerophospholipid components of the plasma membrane, mediates hypothermia-induced Notch activation. Furthermore, the species-specific thermal dependency of Notch signaling is associated with developmental robustness to altered Notch signaling. Our results reveal unique regulatory mechanisms for temperature-dependent neurogenic potentials that underlie developmental and evolutionary adaptations to a range of ambient temperatures in amniotes.
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