ArticleNature communications2022
Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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8citing papers in PubMed, 1 pooled it
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring the Therapeutic Potential of Targeting GH and IGF-1 in the Management of Obesity: Insights from the Interplay between These Hormones and Metabolism.International journal of molecular sciences · 2023Pooled it
- Weight regain after obesity treatment: mechanisms, predictors, and real-world evidence from the IGOBE program.Reviews in endocrine & metabolic disorders · 2026Review
- Energy expenditure and obesity across the economic spectrum.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Definition and diagnostic criteria of clinical obesity.The lancet. Diabetes & endocrinology · 2025Review
- Article
- Total daily energy expenditure and elevated water turnover in a small-scale semi-nomadic pastoralist society from Northern Kenya.Annals of human biology · 2024Article
- Obesity-induced and weight-loss-induced physiological factors affecting weight regain.Nature reviews. Endocrinology · 2023Review
- Total daily energy expenditure has declined over the past three decades due to declining basal expenditure, not reduced activity expenditure.Nature metabolism · 2023Article
Corrections and comments
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Authors and funding
83 authors.
Rebecca Rimbach *Evolutionary Anthropology, Duke University, Durham, NC, USA. rrimbach@gmail.com.ORCID http://orcid.org/0000-0003-3059-0382
Yosuke YamadaNational Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan. yyamada831@gmail.com.ORCID http://orcid.org/0000-0002-4284-6317
Hiroyuki SagayamaFaculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan. sagayama.hiroyuki.ka@u.tsukuba.ac.jp.
Philip N AinslieResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
Lene F AndersonDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, 0317, Oslo, Norway.
Liam J AndersonResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.ORCID http://orcid.org/0000-0003-3130-355X
Lenore ArabDavid Geffen School of Medicine, University of California, Los Angeles, USA.
Issaad BaddouUnité Mixte de Recherche en Nutrition et Alimentation, CNESTEN- Université Ibn Tofail URAC39, Regional Designated Center of Nutrition Associated with AFRA/IAEA, Rabat, Morocco.
Kweku Bedu-AddoDepartment of Physiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Ellen E BlaakMaastricht University, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0002-2496-3464
Stephane BlancNutritional Sciences, University of Wisconsin, Madison, WI, USA.
Alberto G BonomiPhillips Research, Eindhoven, The Netherlands.
Carlijn V C BoutenDepartment of Biomedical Engineering and Institute for Complex Molecular Systems Eindhoven Unversity of Technology, Eindhoven, The Netherlands.ORCID http://orcid.org/0000-0003-1035-5094
Pascal BovetInstitute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Maciej S BuchowskiDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Nancy F ButteDepartment of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, Texas, USA.
Stefan G J A CampsMaastricht University, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0003-2053-1135
Graeme L CloseResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
Jamie A CooperNutritional Sciences, University of Wisconsin, Madison, WI, USA.
Sai Krupa DasJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA, 02111, USA.
Lara R DugasDepartment of Public Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University, Maywood, IL, USA.ORCID http://orcid.org/0000-0002-0692-8585
Ulf EkelundDepartment of Sport Medicine, Norwegian School of Sport Sciences, Oslo, Norway.ORCID http://orcid.org/0000-0003-2115-9267
Sonja EntringerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Medical Psychology, Berlin, Germany.
Terrence ForresterSolutions for Developing Countries, University of the West Indies, Mona, Kingston, Jamaica.
Barry W FudgeUniversity of Glasgow, Glasgow, UK.
Annelies H GorisMaastricht University, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0002-4115-5186
Michael GurvenDepartment of Anthropology, University of California Santa Barbara, Santa Barbara, CA, USA.ORCID http://orcid.org/0000-0002-5661-527X
Catherine HamblyInstitute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK.
Asmaa El HamdouchiUnité Mixte de Recherche en Nutrition et Alimentation, CNESTEN- Université Ibn Tofail URAC39, Regional Designated Center of Nutrition Associated with AFRA/IAEA, Rabat, Morocco.
Marije B HoosMaastricht University, Maastricht, The Netherlands.
Sumei HuState Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Noorjehan JoonasCentral Health Laboratory, Ministry of Health and Wellness, Port Louis, Mauritius.
Annemiek M JoosenMaastricht University, Maastricht, The Netherlands.
Peter KatzmarzykPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Kitty P KempenMaastricht University, Maastricht, The Netherlands.
Misaka KimuraNational Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.
William E KrausDepartment of Medicine, Duke University, Durham, North Carolina, USA.ORCID http://orcid.org/0000-0003-1930-9684
Robert F KushnerNorthwestern University, Chicago, IL, USA.
Estelle V LambertResearch Unit for Exercise Science and Sports Medicine, University of Cape Town, Cape Town, South Africa.
William R LeonardDepartment of Anthropology, Northwestern University, Evanston, IL, USA.
Nader LessanImperial College London Diabetes Centre, Imperial College London, London, UK.
Corby K MartinPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID http://orcid.org/0000-0002-8125-4015
Anine C MedinDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, 0317, Oslo, Norway.ORCID http://orcid.org/0000-0003-4154-6264
Erwin P MeijerMaastricht University, Maastricht, The Netherlands.
James C MorehenResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.ORCID http://orcid.org/0000-0001-5320-0557
James P MortonResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
Marian L NeuhouserDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center and School of Public Health, University of Washington, Seattle, WA, USA.
Theresa A NicklasDepartment of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, Texas, USA.
Robert M OjiamboMoi University, Eldoret, Kenya.
Kirsi H PietiläinenHelsinki University Central Hospital, Helsinki, Finland.ORCID http://orcid.org/0000-0002-8522-1288
Yannis P PitsiladisUniversity of Brighton, Eastbourne, UK.
Jacob Plange-RhuleDepartment of Physiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Guy PlasquiDepartment of Nutrition and Movement Sciences, Maastricht University, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0003-4629-6479
Ross L PrenticeDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center and School of Public Health, University of Washington, Seattle, WA, USA.
Roberto A RabinovichUniversity of Edinburgh, Edinburgh, UK.
Susan B RacetteProgram in Physical Therapy and Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID http://orcid.org/0000-0002-6932-1887
David A RaichlenBiological Sciences and Anthropology, University of Southern California, California, USA.
Eric RavussinPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID http://orcid.org/0000-0003-2129-547X
Rebecca M ReynoldsCentre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Susan B RobertsJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA, 02111, USA.ORCID http://orcid.org/0000-0003-1320-8460
Albertine J SchuitUniversity of Tilburg, Tilburg, The Netherlands.
Anders M SjödinDepartment of Nutrition, Exercise and Sports, Copenhagen University, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-6451-3847
Eric SticeStanford University, Stanford, CA, USA.
Samuel S UrlacherDepartment of Anthropology, Baylor University, Waco, TX, USA.
Giulio ValentiMaastricht University, Maastricht, The Netherlands.
Ludo M Van EttenMaastricht University, Maastricht, The Netherlands.
Edgar A Van MilMaastricht University, Maastricht and Lifestyle Medicine Center for Children, Jeroen Bosch Hospital's-Hertogenbosch, 's-Hertogenbosch, The Netherlands.
Jonathan C K WellsPopulation, Policy and Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK.ORCID http://orcid.org/0000-0003-0411-8025
George WilsonResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
Brian M WoodUniversity of California Los Angeles, Los Angeles, USA.
Jack YanovskiGrowth and Obesity, Division of Intramural Research, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-8542-1637
Tsukasa YoshidaFaculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan.ORCID http://orcid.org/0000-0003-2304-6872
Xueying ZhangInstitute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK.
Alexia J Murphy-AlfordNutritional and Health Related Environmental Studies Section, Division of Human Health, International Atomic Energy Agency, Vienna, Austria.
Cornelia U LoechlNutritional and Health Related Environmental Studies Section, Division of Human Health, International Atomic Energy Agency, Vienna, Austria.
Amy H LukeDivision of Epidemiology, Department of Public Health Sciences, Loyola University School of Medicine, Maywood, Illinois, USA. aluke@luc.edu.ORCID http://orcid.org/0000-0001-8484-9439
Jennifer RoodPennington Biomedical Research Center, Baton Rouge, Louisiana, USA. jennifer.rood@pbrc.edu.ORCID http://orcid.org/0000-0001-5848-2987
Dale A SchoellerBiotech Center and Nutritional Sciences University of Wisconsin, Madison, Wisconsin, USA. dschoell@nutrisci.wisc.edu.ORCID http://orcid.org/0000-0002-5770-3853
Klaas R WesterterpSchool of Nutrition and Translational Research in Metabolism, University of Maastricht, Maastricht, The Netherlands. k.westerterp@maastrichtuniversity.nl.ORCID http://orcid.org/0000-0003-0842-6850
William W WongDepartment of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, Texas, USA. wwong@bcm.edu.ORCID http://orcid.org/0000-0002-7147-5850
John R Speakman *Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK. j.speakman@abdn.ac.uk.ORCID http://orcid.org/0000-0002-2457-1823
Herman Pontzer *Evolutionary Anthropology, Duke University, Durham, NC, USA. herman.pontzer@duke.edu.ORCID http://orcid.org/0000-0003-2397-6543
IAEA DLW Database Consortium
Funding
University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1MResearch BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2005 to 2026
$26.5MPhysiology, Psychology, and Genetics of ObesityZIAHD000641 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YANOVSKI, JACK A. · 2009 to 2025
$24.8MNutrition and Physical Activity Assessment Study (NPAAS)R01CA119171 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian L Neuhouser · 2006 to 2026
$14.3MModeling the epidemiologic transition: Energy expenditure, obesity and diabetesR01DK080763 · NIDDK · LOYOLA UNIVERSITY CHICAGO · PI LUKE, AMY H · 2009 to 2012
$2.4MNCATS NIH HHS UL1 TR001414NCI NIH HHS R01 CA119171NIDDK NIH HHS P30 DK072476NIDDK NIH HHS R01 DK080763
Abstract
Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examine repeated doubly labeled water (DLW) measurements of TEE in 348 adults and 47 children from the IAEA DLW Database (mean ± SD time interval: 1.9 ± 2.9 y) to assess repeatability of TEE, and to examine if TEE adjusted for age, sex, fat-free mass, and fat mass is associated with changes in weight or body composition. Here, we report that repeatability of TEE is high for adults, but not children. Bivariate Bayesian mixed models show no among or within-individual correlation between body composition (fat mass or percentage) and unadjusted TEE in adults. For adults aged 20-60 y (N = 267; time interval: 7.4 ± 12.2 weeks), increases in adjusted TEE are associated with weight gain but not with changes in body composition; results are similar for subjects with intervals >4 weeks (N = 53; 29.1 ± 12.8 weeks). This suggests low TEE is not a risk factor for, and high TEE is not protective against, weight or body fat gain over the time intervals tested.
Indexed as
Adipose TissueAdultBayes TheoremBody CompositionChildDatabases, FactualEnergy MetabolismFemaleHumansIsotope LabelingLongitudinal StudiesMaleMiddle AgedWaterWeight GainWater
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