The involvement of the circFOXM1-miR-432-Gα12 axis in glioma cell proliferation and aggressiveness.

Yong Gong, Shuai Zhang, HongXin Wang, Yunfeng Huang, Xing Fu, Peng Xiang, Tianyu Fan

Open access · goldAbstract read

In one paragraph

Article in Cell death discovery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.3field-weighted citation impact, top 50% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yong Gong *The Affiliated Changsha Central Hospital,Department of Neurosurgery, Hengyang Medical School, University of South China, No.161, Shaoshan South Road, Changsha, Hunan, 410004, China.

Shuai Zhang *The Affiliated Changsha Central Hospital,Department of Neurosurgery, Hengyang Medical School, University of South China, No.161, Shaoshan South Road, Changsha, Hunan, 410004, China.

HongXin WangThe Affiliated Changsha Central Hospital,Department of Neurosurgery, Hengyang Medical School, University of South China, No.161, Shaoshan South Road, Changsha, Hunan, 410004, China.

Yunfeng HuangThe Affiliated Changsha Central Hospital,Department of Neurosurgery, Hengyang Medical School, University of South China, No.161, Shaoshan South Road, Changsha, Hunan, 410004, China.

Xing FuThe Affiliated Changsha Central Hospital,Department of Neurosurgery, Hengyang Medical School, University of South China, No.161, Shaoshan South Road, Changsha, Hunan, 410004, China.

Peng XiangThe Affiliated Changsha Central Hospital,Department of Neurosurgery, Hengyang Medical School, University of South China, No.161, Shaoshan South Road, Changsha, Hunan, 410004, China.

Tianyu FanThe Affiliated Changsha Central Hospital,Department of Neurosurgery, Hengyang Medical School, University of South China, No.161, Shaoshan South Road, Changsha, Hunan, 410004, China. fantianyu2002@st.btbu.edu.cn.ORCID http://orcid.org/0000-0002-9331-2470

Changsha Central Hospital · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating evidence indicates that circFOXM1 (Hsa_circ_0025033) is highly expressed in several cancers; however, the function of circFOXM1 in glioma and the molecular mechanism have not been well explored. In the present study, we found that expression of circFOXM1 was upregulated in both glioma tissues and cell lines. In addition, circFOXM1 knockdown suppressed glioma-cell proliferation, activated apoptosis in vitro, and repressed tumour growth in vivo. Moreover, we clarified that circFOXM1 binds with miR-432, which was downregulated in glioma cells. Furthermore, we indicated that Gα12, a direct target of miR-432, was highly expressed in glioma cells, and Gα12 silencing might limit the progression of glioma. Rescue assays indicated that Gα12 reversed the inhibitory effect of circFOXM1 silencing on glioma-cell tumorigenesis. In conclusion, circFOXM1 acts as a sponge of miR-432 to promote the proliferation and aggressiveness of glioma cells through the Gα12 signalling pathway.

Identifiers

PMID35013157

DOI10.1038/s41420-021-00782-9

PMCPMC8748925

OpenAlexW4205993813

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.