ArticleNature communications2022
Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- Prolonged β2-agonist treatment enhances muscle-specific glucose uptake in individuals with overweight and obesity: a randomized placebo-controlled trial.Nature communications · 2026Trial
- Effect of β2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial.Nature communications · 2023Trial
- Exercise-induced adipose tissue ADRB2-PGC1α-FGF21 signaling protects against pathological cardiac hypertrophy.iScience · 2026Article
- The perineurium integrates leptin with its sympathetic outflow to protect against obesity.Nature metabolism · 2026Article
- Drp1 regulates mitochondrial health and controls skeletal muscle mass through the Erk1/2-Nur77 pathway.Science advances · 2026Article
- Article
- Mechanistic interactions of diet, exercise, and pharmacotherapy in skeletal muscle metabolism: evidence and translational perspectives.Frontiers in physiology · 2026Review
- Development and characterization of an Sf-1-Flp mouse model.JCI insight · 2025Article
- Development and Characterization of abioRxiv : the preprint server for biology · 2025Article
- Assessing clenbuterol's modulation of metabolic and inflammatory pathways in Nile tilapia (Oreochromas niloticous) fed high fat diet.Scientific reports · 2025Article
- Association of the Triglyceride-Glucose Index With Resistant Hypertension and a Nomogram Model Construction.Journal of the American Heart Association · 2024Article
- Possible Extracellular Signals to Ameliorate Sarcopenia in Response to Medium-Chain Triglycerides (8:0 and 10:0) in Frail Older Adults.Nutrients · 2024Review
- The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis.Molecular metabolism · 2024Article
- Role of G protein-coupled receptor kinases (GRKs) in βPharmacology research & perspectives · 2024Article
- A Wearable Integrated Microneedle Electrode Patch for Exercise Management in Diabetes.Research (Washington, D.C.) · 2024Article
- A Novel Role for DOC2B in Ameliorating Palmitate-Induced Glucose Uptake Dysfunction in Skeletal Muscle Cells via a Mechanism Involving β-AR Agonism and Cofilin.International journal of molecular sciences · 2023Article
- The role of sympathetic innervation in neonatal muscle growth and neuromuscular contractures.The FEBS journal · 2023Article
- Article
- Physiological and molecular mechanisms of cold-induced improvements in glucose homeostasis in humans beyond brown adipose tissue.International journal of obesity (2005) · 2023Review
- Muscle hypertrophic effect of inhaled betaThe Journal of physiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 4 institutions in 4 countries.
Jaroslawna Meister *Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA. meister.jaro@gmail.com.ORCID http://orcid.org/0000-0003-4634-1815
Derek B J Bone *Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0002-8962-0307
Jonas R KnudsenDepartments of Nutrition, Exercise and Sports, University of Copenhagen, København, Denmark.ORCID http://orcid.org/0000-0002-5471-491X
Luiz F BarellaMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0003-2211-3842
Thomas J VelenosiFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0001-7016-9037
Dmitry AkhmedovDepartments of Integrative Biology and Pharmacology, Houston Medical School, Houston, TX, 77030, USA.
Regina J LeeMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA.
Amanda H CohenMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA.
Oksana GavrilovaMouse Metabolism Core, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA.
Yinghong CuiMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA.
Gerard KarsentyDepartments of Genetics and Development, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-9253-7627
Min ChenMetabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA.
Lee S WeinsteinMetabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA.
Maximilian KleinertDepartments of Nutrition, Exercise and Sports, University of Copenhagen, København, Denmark.
Rebecca BerdeauxDepartments of Integrative Biology and Pharmacology, Houston Medical School, Houston, TX, 77030, USA.
Thomas E JensenDepartments of Nutrition, Exercise and Sports, University of Copenhagen, København, Denmark.ORCID http://orcid.org/0000-0001-6139-8268
Erik A RichterDepartments of Nutrition, Exercise and Sports, University of Copenhagen, København, Denmark.ORCID http://orcid.org/0000-0002-6850-3056
Jürgen WessMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA. jurgenw@niddk.nih.gov.ORCID http://orcid.org/0000-0003-0818-1232
National Institute of Diabetes and Digestive and Kidney Diseases · USUniversity of Copenhagen · DKColumbia University · USUniversity of British Columbia · CA
Funding
Transcriptomic CoreP01AG032959 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gerard Karsenty · 2010 to 2026
$39.7MRole of G protein-coupled receptors in regulating glucose and energy homeostasisZIADK075021 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI WESS, JURGEN · 2009 to 2025
$37.0MMetabolic Studies of Mouse Models of Obesity and DiabetesZICDK070002 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GAVRILOVA, OKSANA · 2009 to 2025
$15.0MRole of Gs-alpha in central regulation of energy and glucose metabolismZIADK043315 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI WEINSTEIN, LEE · 2009 to 2025
$9.0MRole of the Gnas Gene in Metabolic RegulationZIADK043313 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI WEINSTEIN, LEE · 2009 to 2025
$4.9MRole of Gs-alpha in regulation of skeletal muscle metabolismZIADK043317 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI WEINSTEIN, LEE · 2009 to 2025
$2.0MNIA NIH HHS P01 AG032959
Abstract
Activation of the sympathetic nervous system causes pronounced metabolic changes that are mediated by multiple adrenergic receptor subtypes. Systemic treatment with β
Indexed as
AnimalsBiochemical PhenomenaCellular ReprogrammingClenbuterolFemaleGlucoseHomeostasisHypoglycemic AgentsInsulin ResistanceMaleMetabolic DiseasesMetabolomicsMiceMice, KnockoutMuscle Fibers, SkeletalMuscle, SkeletalADRB2 protein, mouseClenbuterolGlucoseHypoglycemic AgentsReceptors, Adrenergic, beta-2
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.