ArticleNature communications2022
Focal neural perturbations reshape low-dimensional trajectories of brain activity supporting cognitive performance.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Frontoparietal Hub Connectivity Integrates Information from Multiple Sources.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Estimating trial-wise modulation of functional connectivity using event-related fMRI.bioRxiv : the preprint server for biology · 2026Article
- Frontoparietal Hub Connectivity Integrates Information from Multiple Sources.bioRxiv : the preprint server for biology · 2026Article
- Electromagnetic field stimulation modulates working memory and cortical alpha oscillations in healthy adults.Scientific reports · 2026Article
- Magnetoencephalography Dimensionality Reduction Informed by Dynamic Brain States.The European journal of neuroscience · 2025Article
- The morphospace of the brain-cognition organisation.Nature communications · 2024Article
- Internal Representations Are Prioritized by Frontoparietal Theta Connectivity and Suppressed by alpha Oscillation Dynamics: Evidence from Concurrent Transcranial Magnetic Stimulation EEG and Invasive EEG.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches.Psychiatry research · 2024Article
- Improving reduced-order models through nonlinear decoding of projection-dependent outputs.Patterns (New York, N.Y.) · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The emergence of distributed patterns of neural activity supporting brain functions and behavior can be understood by study of the brain's low-dimensional topology. Functional neuroimaging demonstrates that brain activity linked to adaptive behavior is constrained to low-dimensional manifolds. In human participants, we tested whether these low-dimensional constraints preserve working memory performance following local neuronal perturbations. We combined multi-session functional magnetic resonance imaging, non-invasive transcranial magnetic stimulation (TMS), and methods translated from the fields of complex systems and computational biology to assess the functional link between changes in local neural activity and the reshaping of task-related low dimensional trajectories of brain activity. We show that specific reconfigurations of low-dimensional trajectories of brain activity sustain effective working memory performance following TMS manipulation of local activity on, but not off, the space traversed by these trajectories. We highlight an association between the multi-scale changes in brain activity underpinning cognitive function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.